An Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease

Chen, Zeliang; Liang, Hongwei; Chen, Xi; Yuan, Ke; Zhou, Zhen; Yang, Mingjuan; Zen, Ke; Yang, Ruifu; Liu, Chao; Zhang, Chenyu

doi:10.1038/cr.2016.21

Cited by 46 publications

(57 citation statements)

References 12 publications

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“…Apart from circulating EBV-encoded miRNAs, other virus including Kaposi sarcoma-associated herpesvirus (KSHV), BK virus (BKV), Polyomavirus JC (JCPyV), and Papillomaviruses (PVs) derived miRNAs in blood circulation were also found to be a hopeful approach for the exploitation of disease markers [6,10,[19][20][21][22]. Recently, Chen and colleagues reported that several miRNA-like RNA fragments can be predicted in Ebola virus genome and they successfully confirmed the existence of miR-VP-3p in the serum samples of patients with Ebola virus disease (EVD), moreover, monitoring the levels of serum miR-VP-3p may use as an early indicator of EVD [23]. Collectively, these observations point out a novel vision for the use of viral encoded miR-NAs as minimal-invasive markers for diagnosing, outcome evaluation, and therapeutic effectiveness assessment of virus associated diseases.…”

Section: Introductionmentioning

confidence: 99%

Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents

Wang

Zhang

2019

ExRNA

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Circulating microRNAs (miRNAs) are exceptionally stable molecule markers in extracellular environments for various diseases. Importantly, some circulating miRNAs that were encapsulated in extracellular microvesicles (MVs) have been identified as critical mediators of intercellular communication, and function as novel cell-cell crosstalk generegulators. Burgeoning evidence has demonstrated that several types of viruses, including the human cytomegalovirus (HCMV), can encode various miRNAs that play essential roles in disturbing the translation of either the eukaryotic host's genes or virus own during multiple pathophysiological processes. Recently, HCMV-encoded miRNAs have also been uncovered in human circulation, moreover, some circulating HCMV-encoded miRNAs showed specific expression patterns in different diseases with no precise aetiology. In particular, dysregulated HCMV-encoded miRNAs can effectively regulate the host genes regulation, and were implicated in disease development. Given the clinical impact of circulating miRNAs and their abilities to profoundly modulate specific recipient cells, we postulate that characterization of altered HCMV-encoded miRNAs in host circulation may afford valuable insights into developing non-invasive diagnostic biomarkers and clarifying the potential pathophysiological mechanism for various complex diseases, even if the research on circulating HCMV miRNAs is just emerging. The focus of this review is on summarizing the updates on current developments and perspectives for diagnostic and discriminative usefulness of circulating HCMV-encoded miRNAs in various diseases, including essential hypertension, oral lichen planus disease, chronic hepatitis B and type 2 diabetes. We also review the physiological and pathophysiological effects of HCMV-encoded miRNAs on disease development and progression.

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Section: Introductionmentioning

confidence: 99%

Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents

Wang

Zhang

2019

ExRNA

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“…In addition, v-miRNAs were also considered as biomarkers in many virally infected diseases. miR-VP-3p was found to be present in the sera of EBOV-infected patients but not in healthy controls, and this v-miRNA was detectable in the serum prior to the detection of viral genomic RNA, indicating that miR-VP-3p may serve as a biomarker for early diagnosis of EBOV (114). HCMV-encoded miR-US4-1 serves as a biomarker for IFNα treatment potency in the serum of hepatitis B patients (135).…”

Section: Therapeutic Potential Of Viral Mirnasmentioning

confidence: 99%

“…Ebola virus (EBOV) is a negative-sense RNA virus that causes severe infectious disease with a high mortality rate of 83-90%. To date, few studies have identified miRNA-like small RNA encoded by EBOV (114)(115)(116)(117). The first report was by Liang et al, who predicted that three mature miRNAs (EBOV-miR-1-5p,-3p, and miR-2-3p) are formed from two pre-miRNAs (EBOV-pre-miR-1 and EBOV-pre-miR-2) using the host cellular machinery.…”

Section: Ebola Virusmentioning

confidence: 99%

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The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection

et al. 2020

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MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection. In the last decade, multiple DNA and RNA viruses have been shown to produce miRNAs known as viral miRNAs (v-miRNAs) so as to evade the host immune response. In this review, we highlight the origin and biogenesis of viral miRNAs during the viral lifecycle. We also explore the role of viral miRNAs in immune evasion and hence in maintaining chronic infection and disease. Finally, we offer insights into the underexplored role of viral miRNAs as potential targets for developing therapeutics for treating complex viral diseases.

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“…Hence, for the early diagnosis of disease, the role of noninvasive circulating miRNA has come into the picture as a biomarker. In the year 2016, Chen et al () conducted the observational study to prove whether the miRNA‐like fragments, miR‐VP‐3p, serve as a potential biomarker for the primeval detection of Ebola virus infection or not. For this, they compared the Ebola virus‐positive patients with the negative ones and observed the elevated level of miR‐VP‐3p in the Ebola‐positive patients which was not detectable in the Ebola negative patients.…”

Section: Role Of Circulatory Mirna For the Diagnosis Of Human Infectimentioning

confidence: 99%

Emerging role of circulating microRNA in the diagnosis of human infectious diseases

Ojha

Nandani

Pandey

et al. 2018

Journal Cellular Physiology

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The endogenic microRNAs (miRNA) are evolutionary, conserved, and belong to a group of small noncoding RNAs with a stretch of 19-24 nucleotides. The miRNAs play an indispensable role in gene modulation at the posttranscriptional level, inclusive of stem-cell differentiation, embryogenesis, hematopoiesis, metabolism, immune responses, or infections. The miRNAs secreted from the cells and their presence in the biological fluids signifies the regulatory role of circulating miRNAs in the pathogenesis. The phenomenal expression levels of circulating miRNAs in serum or plasma during infection makes them the potential therapeutic biomarkers for the diagnosis of assorted human infectious diseases. In this article, we have accentuated the methods for the profiling of circulating miRNA as well as the importance of miRNA as biomarkers for the diagnosis of human infectious diseases. To date, numerous biomarkers have been identified for the diagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection. Nevertheless, the noninvasive diagnostic approach, with the aid of biomarkers, currently plays a decisive role in the untimely diagnosis of human infections. So, in the near future, the exploitation of circulating miRNAs as therapeutic biomarkers for the diagnosis of human infections will help us to cure the associated diseases promptly and effectively.

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An Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease

Cited by 46 publications

References 12 publications

Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents

Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents

The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection

Emerging role of circulating microRNA in the diagnosis of human infectious diseases

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