An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives

Aryl α, β-Unsaturated Ketones as Efficient Precursor for Synthesis of Unsaturated 1,3-oxazine-2-amines under Solvent-free Conditions

“…These oxazines are exists more than ten isomeric structures depend upon the relative position of unsaturation and the hetero atoms (Manjula et al, 2009). These isomeric structural moieties are important for their biological activities such as antimicrobial, antiplasmodial (Mathew et al, 2010), anti-cancer (Elarfi and Al-Difar, 2012), anti-depressants (Tiwari et al, 2011), cytotoxicity , antiosteoplastic (Zhou et al, 2006), anti-tumour (Wang et al, 2008), anti-oxidant (Ando et al, 2006), antituberculosis (Benameur et al, 1996), anti-neoplastic (Roy et al, 2009), antagonists (Blaser et al, 2012), anti-inflammatory (Seal et al, 1997(Seal et al, ), anti-infectants (brudli et al, 2010, IKB kinase beta (Akhter et al, 2011) and PTP-1B inhibition (Gothi et al, 2011). These oxazine derivatives were applied for improving the super resolution microscope (Oh et al, 2010), synthesis of eosinophils (Cho et al, 2006), identification and separation of neutrophils (Lee et al, 2013).…”

Aryl Chalcones as Efficient Precursors for Deriving Oxazine: Solvent-Free Synthesis and Antimicrobial Activities of some Oxazine-2-amines

“…Elarfi and Al-difar [4] have synthesised some 1,3-oxazine derivatives by solvent-assisted method from chalacones and urea. More than 75 % yield of dihydro-2 H-benzo-and naphtho-1,3-oxazine derivatives were prepared by Mathew et al [3] using eco-friendly method.…”

“…Numerous solvent assisted and solvent-free synthetic methods were available for synthesis of oxazine derivatives [23]. Now-a-days scientists, organic chemists are interested for solvent-free synthesis [3,[24][25][26][27][28][29][30][31][32]. Hetero Diels-alder reaction [2], ring closure [33], Betti base induced condensation [24][25][26][27][28][29][30][31][32], Mannich type condensation-cyclization [3] and cyclization of chalcones [4] were used for synthesis of oxazine derivatives.…”

“…The important medicinal activities of these oxazines are anti-bacterial [2][3][4], anti-fungal [2][3][4], antiplasmodial [5], anti-cancer [6], anti-depressants [7], cytotoxicity [8], anti-osteoplastic [9], anti-tumour [10], anti-oxidant [11], anti-tuberculosis [12], anti-neoplastic [13], antagonists [14], anti-inflammatory [15], anti-infectants [16], IKB kinase beta [17] and PTP-1B inhibition [18].…”

Infrared and NMR Spectral Hammett Correlations in 4-(2-Naphthyl)-5,6-Dihydro-6-(Substituted Phenyl)-⁴H-1,3-Oxazine-2-Amines

“…The unsaturated cyclic oxazine-2-amines are important bioactive molecules. They possess many biologically activities such as antimicrobial [9], anti-plasmodial [10], anti-cancer [11], anti-depressants [12], cytotoxicity [13], anti-osteoplastic [14], anti-tumour [15], anti-oxidant [16], anti-tuberculosis [17], anti-neoplastic [18], antagonists [19], antiinflammatory [20] anti-infectants [21], IKB kinase beta [22], PTP-1B inhibition [23] and insect antifeedant activities [24].…”