An Edwardsiella piscicida esaS mutant reveals contribution to virulence and vaccine potential

Edwardsiella tarda Attenuates Virulence upon Oxytetracycline Resistance

“…Mutants in bacterial virulence have been attractive targets for the development of vaccines to prevent edwardsiellosis in recent years. − Deletion mutants of T3SS in E. tarda have been used as a live attenuated vaccine in turbot, which has been authorized for use in aquaculture .…”

Comparative genomics of Edwardsiella anguillarum and Edwardsiella piscicida isolated in Taiwan enables the identification of distinctive features and potential virulence factors using Oxford‐Nanopore MinION® sequencing

“…In E. piscicida, several outer membrane proteins, rOmpI, rOmpX, and OmpC, and flagellar proteins, FliC, resulted in high relative per cent survival (RPS) (Liu, Zhang, et al, 2017;Liu, Sun, & Wu, 2017;Liu et al, 2016a andLiu et al, 2016b;Choe et al, 2022). The E. piscicida mutant strain with PhoP/PhoQ and esaS genes and further vaccinated in channel catfish provided high RPS compared to the non-mutant strain (Edrees et al, 2020;Sayed et al, 2021Sayed et al, , 2022. Notably, unlike E. piscicida, there are few studies evaluating E. anguillarum vaccines in fish, except for outer membrane protein A vaccines in Japanese Eel (Anguilla japonica) (Guo et al, 2019;LiHua et al, 2019).…”