An effect in vivo of clomiphene on the rate of conversion of androstenedione-C14 to estrone-C14 and estradiol-C14 by the canine ovary

Engels, J.A.; Friedländer, Rosa; Eik‐Nes, Kristen B.

doi:10.1016/0026-0495(68)90147-9

Cited by 17 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[98][99][100][101][102][103][104] Recently reviewed information has led to the sug gestion that clomiphene citrate may act at the level of the ovary in its own right or else synergize with pituitary gonadotropins in this connection. 64,[105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120]…”

Section: Ovarymentioning

confidence: 99%

Clomiphene Citrate-Initiated Ovulation: A Clinical Update

Adashi¹

1986

Semin Reprod Med

View full text Add to dashboard Cite

Section: Ovarymentioning

confidence: 99%

Clomiphene Citrate-Initiated Ovulation: A Clinical Update

Adashi¹

1986

Semin Reprod Med

View full text Add to dashboard Cite

“…In spite of the fact that clomiphene (l-[/)-(jS-diethyl-aminoethoxy)-phenyl] 1,2-diphenyl-2-chloroethylene) is now widely used for the induction of ovu¬ lation in anovulatory women, the views on the mode of action of this substance are rather contradictory. Many authors assume a primary effect on the hypothalamo-hypophysial system (Greenblatt, 1961; Roy, Greenblatt, Mahesh & Jungck, 1963;Thompson & Mellinger, 1965;Wyss, Naville, Keller & Gysel, 1966;Bardin, Ross & Lipsett, 1967;Jacobson, Marshall & Ross, 1968), but since the studies of Smith, Smith & Kistner (1963) and Smith & Day (1963), a direct effect on the ovary has also been under discussion (Breckwoldt & Bettendorf, 1966;Hammerstein, 1967; Engels, Friedlander & Eik-Nes, 1968). Investigations in laboratory animals have been complicated by the obser¬ vation that the general effect of clomiphene in female rats is to inhibit ovu¬ lation.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Anti-Ovulatory and Ovulatory Action of Clomiphene Citrate in the Rat

Döcke¹

1971

Reproduction

View full text Add to dashboard Cite

To study the site and mechanism of its ovulation-inhibiting effect, clomiphene citrate was implanted bilaterally into the hypothalamus and hypophysis of adult di-oestrous rats and of prepuberal females which were also treated with oestradiol benzoate. The results suggest that this effect is primarily due to the action of clomiphene on the anterior pituitary. The anti-oestrogenic activity of clomiphene may prevent the action of oestrogen on the hypophysis, thus suppressing the increased gonadotrophin secretion leading to ovulation. The ovulation-inducing effect of clomiphene was investigated in adult female rats which had been made anovulatory by destruction of the suprachiasmatic nuclei. Bilateral implantation of a small quantity of clomiphene citrate into the ventromedial-arcuate region resulted in corpus luteum formation and ovulation in these animals. A direct stimulation of the central hypothalamus is thought to be responsible for the ovulatory action of clomiphene in rats with cerebral lesions.

show abstract