An effect of combination of resveratrol with vitamin D3 on modulation of proinflammatory cytokines in diabetic nephropathy induces rat

Maity, Barnali; Bora, Manajit; Sur, Debjeet

doi:10.1007/s13596-018-0311-4

Cited by 12 publications

(8 citation statements)

References 46 publications

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“…additionally, Dispensation of high dose vitamin D for induced visible ordinary structures of renal corpuscles and utmost of tubular lining epithelium of STZ rats. Collectively we proposition that high dose vitamin D improved renal histology in STZ induced DN in resemblance with [33,34] .…”

Section: Discussionsupporting

confidence: 63%

Effect of Low and High Doses of Vitamin D on Sreptozotocin-induced Diabetic Nephropathy in Adult Male Albino Rats: Histological and Immunohistochemical Sudy

Mohamady

Mostafa²,

Mohamed³

2019

Egyptian Journal of Histology

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Background: Diabetic nephropathy is an important instigate of persistent kidney ailment problem and irrevocably renal catastrophe. Vitamin D (VD) insufficiency is documented as a worldwide health delinquent and lately pondered as a conscientious factor in the onset and progression of diabetes mellitus (DM). Aim: This research paper was premeditated to explore the probable upshot of low and high doses of vitamin D on a rat model of diabetic nephropathy. Material and Methods: Forty adult male albino rats were segregated into four groups: Group I (control group). Group II (the diabetic nephropathy group): given streptozotocin intraperitoneal. Group III (the low dose VD group): rats were given streptozotocin then vitamin D orally as 8000 IU/kg/day. Group IV (the high dose VD group): rats were given streptozotocin then vitamin D orally as 20,000 IU/kg/day. After complete12 weeks from the beginning of the experiment, rats were sacrificed. Kidney specimens were handled and assayed by histological and Immunohistochemical procedures. Results: The diabetic nephr0pathy group revealed distortion of glomeruli, tubular distortion. mononuclear permeation and epithelial desquamation. Congested dilated glomeruli, peritubular blood vessels and interstitial outpouring of blood were also noticed. EM examination of proximal and distal c0nv0luted tubules exhibited multiple vacuoles. thickening of basement membrane and destructed mitochondria were also seen. Group III showed improvement of these changes and Group IV showed amelioration of most of these changes. Conclusion: High dose of vitamin D ameliorates experimentally induced diabetic nephropathy.

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Section: Discussionsupporting

confidence: 63%

Effect of Low and High Doses of Vitamin D on Sreptozotocin-induced Diabetic Nephropathy in Adult Male Albino Rats: Histological and Immunohistochemical Sudy

Mohamady

Mostafa²,

Mohamed³

2019

Egyptian Journal of Histology

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“…Such cooperative effects of RE and vitamin D3 were even reported in diabetic nephropathy. A combination of RE and vitamin D3 was shown to effectively reduce TNF-α and IL-6 expression when compared to individual drug treatments [218]. A combination of glucan, vitamin C, and RE demonstrated a strong anti-tumor potential by suppressing the growth of breast and lung tumors in in vivo models, which was superior to that of the individual agents [188].…”

Section: Resveratrol As a Complementary Therapymentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

442

293

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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects.In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

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“…Coronavirus has been shown to activate Toll-Like Receptor 4, increase pro-in ammatory cytokines IL-1, IL-6, CCL5 (RANTES) and TNF-α leading to an unbalanced in ammatory response and damaging in ammation [34][35][36][37] . In contrast, RV has been shown to reduce in ammation via a variety of mechanisms (Figure 1) [11][12][13]38 . RV has been demonstrated to inhibit TLR4 activation, decreasing the release of in ammatory cytokines in the macrophages of patients with COPD, and inhibit the proin ammatory transcription factor NF-κB 14,19,39 .…”

Section: Anti-in Ammatory Effectsmentioning

confidence: 99%

“…Vitamin D3 was included in the treatment protocol as an adjunct to RV based upon prior research showing that it has synergistic anti-in ammatory effects, inhibiting IL-6 and TNF-α 11 . Both treatment arms received a single 100,000 IU dose of D3 to quickly assure adequate serum concentrations of D3, as well as to potentially remove vitamin D3 de ciency as a confounding variable, noting that multiple publications raised concerns that vitamin D3 de ciency might be associated with worse outcomes in COVID-19 50,51 .…”

Section: Vitamin D3mentioning

confidence: 99%

Randomized Double-blind Placebo-controlled Proof-of-concept Trial of Resveratrol for Outpatient Treatment of Mild Coronavirus Disease (COVID-19)

McCreary

Schnell

Rhoda³

2021

Preprint

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Resveratrol is a polyphenol that has been well studied and has demonstrated anti-viral and anti-inflammatory properties that might mitigate the effects of COVID-19. Outpatients (N=105) were recruited from central Ohio in late 2020. Participants were randomly assigned to receive placebo or resveratrol. Both groups received a single dose of Vitamin D3 which was used as an adjunct. The primary outcome measure was hospitalization within 21 days of symptom onset; secondary measures were ER visits, incidence of pneumonia and pulmonary embolism. Five patients chose not to participate after randomization. Twenty-one day outcome was determined of all one hundred participants (mean [SD] age 55.6 [8.8] years; 61% female) (or their surrogates). There were no clinically significant adverse events attributed to resveratrol. Outpatients in this phase 2 study treated with resveratrol had a lower incidence compared to placebo of: hospitalization (2% vs. 6%, RR 0.33, 95% CI 0.04-3.10), COVID-related ER visits (8% vs. 14%, RR 0.57, 95% CI 0.18-1.83), and pneumonia (8% vs. 16%, RR 0.5, 95% CI 0.16-1.55). One patient (2%) in each group developed pulmonary embolism (RR 1.00, 95% CI: 0.06-15.55). This underpowered study was limited by small sample size and low incidence of primary adverse events. A larger trial could determine efficacy.TRIAL REGISTRATIONS: ClinicalTrials.gov NCT04400890 26/05/2020; FDA IND #150033 05/05/2020

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An effect of combination of resveratrol with vitamin D3 on modulation of proinflammatory cytokines in diabetic nephropathy induces rat

Cited by 12 publications

References 46 publications

Effect of Low and High Doses of Vitamin D on Sreptozotocin-induced Diabetic Nephropathy in Adult Male Albino Rats: Histological and Immunohistochemical Sudy

Effect of Low and High Doses of Vitamin D on Sreptozotocin-induced Diabetic Nephropathy in Adult Male Albino Rats: Histological and Immunohistochemical Sudy

Potential Adverse Effects of Resveratrol: A Literature Review

Randomized Double-blind Placebo-controlled Proof-of-concept Trial of Resveratrol for Outpatient Treatment of Mild Coronavirus Disease (COVID-19)

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