With the development of infrared guidance technology, the guidance accuracy and anti-jamming ability of infrared guided missile are improved constantly. Based on the analysis of the mechanism of the third generation quaternary cross-shaped detector and the influence of jamming signals on the target recognition, the detector model and the mid-infrared laser interference model based on the time-domain feature analysis are established in this paper. According to the simulation results, we use the continuous and pulsed mid-infrared laser to experiment the jamming effectiveness of the quaternary cross-shaped detector. It is found that compared with continuous mid-infrared laser, pulsed mid-infrared laser is easier to make the detector lose the target and difficult to recover the tracking.