In this article, a highly efficient power module is presented with two class-E power amplifiers and an adaptive power combiner for transmitting output powers >100 W at 6.78 MHz in a wireless power transfer system. The losses caused by the combiners and interstage matching circuits or mismatching between the amplifier, and the combiners can significantly reduce the overall efficiency of the power module. To achieve an efficient combination of the output amplifier signals, the adaptive power combiner is proposed based on the consideration of the optimum load impedance characteristics of the power amplifiers. The input impedance of the combiner is designed using series capacitors and resistors between the two input ports of the combiner and the two output signals of the class-E amplifiers at the optimum load condition. The output performances of the proposed module can decrease based on the component mismatch between the two power amplifiers. The proposed power module was implemented on an FR4 PCB, with a 15 mm metal heat sink, and demonstrated an output power of 123.3 W, a power-added efficiency of 85.7%, and a power gain of 25.6 dB at 6.78 MHz. The second harmonic suppression of the module was 37 dBc.