2017
DOI: 10.1007/s10593-017-2185-7
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An efficient and green synthesis of polyfunctionalized spirothiazolidin-4-ones using sulfonated mesoporous silica as a reusable catalyst

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Cited by 10 publications
(5 citation statements)
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“…Based on these prior observations relating to the synthesis of sulfonamide derivatives [42, 43] and bioactive nitrogen-containing heterocyclic agents [44–48] we envisaged that sulfonamides bearing acetamide pharmacophores could be very efficient for antimicrobial and anticancer activity. In the present work, we report the synthesis of some novel sulfonamide- N 4 -acetamide derivatives and their evaluation of their cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines.…”
Section: Introductionmentioning
confidence: 99%
“…Based on these prior observations relating to the synthesis of sulfonamide derivatives [42, 43] and bioactive nitrogen-containing heterocyclic agents [44–48] we envisaged that sulfonamides bearing acetamide pharmacophores could be very efficient for antimicrobial and anticancer activity. In the present work, we report the synthesis of some novel sulfonamide- N 4 -acetamide derivatives and their evaluation of their cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines.…”
Section: Introductionmentioning
confidence: 99%
“…E. M. Hussein and colleagues 42 used sulfonated mesoporous silica (MCM-SO 3 H) as a heterogeneous and reusable acidic catalyst to establish a simple and effective one-pot production of polyfunctionalized spirothiazolidin-4-ones (23) ( Scheme 5 ). This approach avoided the use of harmful solvents, resulting in greater yields under benign conditions as compared to the previously described synthetic procedures for spirothiazolidin-4-one molecules.…”
Section: Recent Advances In the Synthesis Of Spiro-thiazolidines Unde...mentioning
confidence: 99%
“…Figure b displays another typical method to prepare −SO 3 H-functionalized solid catalysts, which need two steps: The −SH group is first grafted on a solid support, using 3-mercaptopropyltriethoxysilane (MTPS) as the precursor of the −SH groups by refluxing it in toluene. This step is followed by the oxidation of −SH groups into −SO 3 H groups by H 2 O 2 . , The latter strategy effectively avoids the use of concentrated sulfuric acid or fuming sulfuric acid. However, the process for −SH modification in this approach is time-consuming (>12 h).…”
Section: Introductionmentioning
confidence: 99%
“…This step is followed by the oxidation of −SH groups into −SO 3 H groups by H 2 O 2 . 34,35 The latter strategy effectively avoids the use of concentrated sulfuric acid or fuming sulfuric acid. However, the process for −SH modification in this approach is time-consuming (>12 h).…”
Section: ■ Introductionmentioning
confidence: 99%