An efficient one pot multicomponent synthesis of pyrano pyrazoles using Cu2+ doped Ni-Zn nano ferrite catalyst

Mandle, U.M.; Pachpinde, Amol M.; Shinde, B.L.

doi:10.1016/j.matpr.2020.03.583

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Shinde et al [103] . established a novel and effective method for the synthesis of pyrano(2,3‐ c )pyrazoles 5 , utilizing a one‐pot multicomponent reaction including ethyl acetoacetate 3 , hydrazine hydrate 2 , aromatic aldehydes 1 , and malononitrile 4 (Scheme 38).…”

Section: Synthesis Of Pyrazole Derivatives Through the Magnetic Nanop...mentioning

confidence: 99%

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

Sharma,

Suman,

Kaith

et al. 2024

ChemistrySelect

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In the present era, the concept of green in organic synthesis has a unique and irreplaceable place. Specifically, nanoparticle has gained much more attention due to its various properties related to the concept of green chemistry. In this context, magnetic nanoparticle has been widely used in the organic synthesis over last one decade. Among organic compounds, pyrazole and its scaffolds are recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules and other valuable candidates. Several commercial drugs such as Sildenafil, Rimonabant, Celecoxib and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. Accordingly, the magnetic nanoparticles have an irreplaceable place in the synthesis of pyrazole derivatives and it is a green and easy methodology to the organic chemists. The present manuscript represents the assimilation of literature pertaining to green aspects of magnetic nanoparticles for the synthesis of highly diversified and valuable derivatives of pyrazole.

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Section: Synthesis Of Pyrazole Derivatives Through the Magnetic Nanop...mentioning

confidence: 99%

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

Sharma,

Suman,

Kaith

et al. 2024

ChemistrySelect

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“…Using the same substrates, Mandle and co‐workers reported a one‐pot synthesis of pyranopyrazole derivatives catalyzed by magnetically separable Cu 2+ doped Ni−Zn nano ferrites [56] . The catalytic efficacy of nano ferrites with various compositions were evaluated for pyranopyrazole synthesis, and it was observed that Ni 0.5 Cu x Zn 0.5‐x Fe 2 O 4 (x=0.3) ferrite produced the highest yield of 95 % in the shortest period of time.…”

Section: Classificationmentioning

confidence: 99%

Nickel‐Catalyzed Multicomponent Reactions: An Overview

Nathaniel¹,

Dhanya²,

Saranya³

et al. 2022

ChemistrySelect

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Multicomponent reactions have received a lot of attention as a potential method for the synthesis of a wide range of complex organic molecules. Rapid development is being made in this field because of its importance in the chemical, pharmaceutical, biological, and industrial areas. Nickel is a versatile catalyst that can be used in a variety of synthetic transformations. In this review, we discuss the advancements in the field of Nickelcatalyzed multicomponent reactions, covering the literature up to 2021.

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“…An efficient and novel magnetically-separable catalyst, Cu 2+ doped Ni-Zn nano ferrite composite (Ni 0.5 Cu 0.3 Zn 0.2 Fe 2 O 4 ), was designed by Mandle et al via the sol-gel approach [ 100 ]. The four-component reaction of pyranopyrazoles ( 147 ) from malononitrile ( 3 ), hydrazine hydrate ( 11 ), ethyl acetoacetate ( 12 ), and various substituted benzaldehydes ( 146 ) was catalysed by 20 mg of Ni 0.5 Cu 0.3 Zn 0.2 Fe 2 O 4 catalyst in the presence of ethanol under reflux condition ( Scheme 42 ), giving excellent yields (91–95%) in 30 min.…”

Section: With Miscellaneous Materials and Composites As Catalystsmentioning

confidence: 99%

Advances in Pyranopyrazole Scaffolds’ Syntheses Using Sustainable Catalysts—A Review

et al. 2021

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Heterogeneous catalysis plays a crucial role in many chemical processes, including advanced organic preparations and the design and synthesis of new organic moieties. Efficient and sustainable catalysts are vital to ecological and fiscal viability. This is why green multicomponent reaction (MCR) approaches have gained prominence. Owing to a broad range of pharmacological applications, pyranopyrazole syntheses (through the one-pot strategy, employing sustainable heterogeneous catalysts) have received immense attention. This review aimed to emphasise recent developments in synthesising nitrogen-based fused heterocyclic ring frameworks, exploring diverse recyclable catalysts. The article focused on the synthetic protocols used between 2010 and 2020 using different single, bi- and tri-metallic materials and nanocomposites as reusable catalysts. This review designated the catalysts’ efficacy and activity in product yields, reaction time, and reusability. The MCR green methodologies (in conjunction with recyclable catalyst materials) proved eco-friendly and ideal, with a broad scope that could feasibly lead to advancements in organic synthesis.

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An efficient one pot multicomponent synthesis of pyrano pyrazoles using Cu2+ doped Ni-Zn nano ferrite catalyst

Cited by 6 publications

References 25 publications

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

Nickel‐Catalyzed Multicomponent Reactions: An Overview

Advances in Pyranopyrazole Scaffolds’ Syntheses Using Sustainable Catalysts—A Review

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