An efficient preparation of porous polymeric microspheres by solvent evaporation in foam phase

Yu, Yang; Li, Guiying; Han, Wanqing; Zhu, Linhua; Tian, Shansi; Wang, Hong; Sun, Yingjuan; He, Yanping

doi:10.1016/j.cjche.2020.09.002

Cited by 8 publications

(2 citation statements)

References 34 publications

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“…The porosity of porous microparticles plays a significant role in determining the capacity efficiency of the microparticles and influences the release kinetics [4], where the size and the structure of the pores are the crucial factors affecting the properties of porous microspheres. The same traditional processes used to produce non-porous microparticles may be used to produce porous ones (i.e., atomization [5][6][7], solvent evaporation [8], suspension polymerization [9]) but with the addition of a poreforming agent (porogen). The porogen is usually unreactive towards the other materials involved in the process and works according to a solvent casting/particulate leaching mechanism.…”

Section: Introductionmentioning

confidence: 99%

Online Microfluidic Production of Sustainable Cyrene™-Derived Porous Microparticles

et al. 2023

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The use of sustainable raw materials is now a necessity in all industries, including the production of porous microparticles. Cyrene™ is a cellulose-derived compound that is readily prepared through the reduction of the α,β-unsaturation of levoglucosenone (LGO)—a wood-based platform molecule. In this work, the importance of Cyrene™ as a potential bio-based molecule to produce sustainable porous microparticles is demonstrated. First, a methacrylic derivative of Cyrene™ (m-Cyrene) was synthesized. A microfluidic co-flow device was then established to produce m-Cyrene-based oil-in-water (O/W) controlled-size emulsions and to polymerize them by ultraviolet (UV) radiation in a vial. The continuous phase was a sodium dodecyl sulfate aqueous solution, and the dispersed phase was a mixture of m-Cyrene with methacrylic anhydride (MAN) at two different mass concentrations (i.e., 1 wt.% MAN and 92 wt.% MAN) and 2,2-dimethoxy-2-phenylacetophenone (DMPA) as a photoinitiator. The process used the lowest possible quantity of raw materials and avoided excessive purifications to produce homogeneous porous m-Cyrene-MAN microparticles. The controlled size and homogeneous size distribution of the produced polymer microparticles were confirmed by scanning electron microscope (SEM) images. The 3D microstructure as well as the porosity were determined using X-ray microtomography. The high-resolution 3D images produced indicate that the pores of the microparticles are homogeneous and that their porosity is controllable through the concentration of MAN in the monomer mixture (porosity of 30% for a 1 wt.% MAN ratio and 2% for a 92 wt.% MAN ratio). Such porosity control is very important for future potential encapsulation processes that require precise release control.

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Section: Introductionmentioning

confidence: 99%

Online Microfluidic Production of Sustainable Cyrene™-Derived Porous Microparticles

et al. 2023

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“…[11][12][13] Microspheres can contain 10-90% w/w active or core ingredient in general. The solvent-evaporation is the most frequently used method for microsphere dosage form preparation [14][15][16] . In this method, a solution of drug and a combination of polymers is emulsified with another solvent with the help of an emulsifying agent, and the formulations are prepared with different stirring speed (RPM) in an overhead stirrer.…”

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confidence: 99%

Evaluation of the Influence of Stirring Speed on the Release Kinetics of Fexofenadine HCl Polymeric Microspheres

Arefin

Habib

Mostafa

et al. 2021

Biosci., Biotech. Res. Asia

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Microspheres, a potential drug delivery approach, has opened a new era for attaining versatile release patterns needed. By optimizing the formulation variables, they can be prepared to obtain targeted release, immediate release, sustained release patterns. The release of the active drug material depends upon a number of formulation parameters such as polymers, stirring speed (rpm), methodology, surfactants, etc. Fexofenadine hydrochloride (HCl) is a second generation antihistamine. Our present research has explored the effects of using different rpm (600- 1000 rpm) in preparing fexofenadine hydrochloride (HCl) microspheres by emulsion solvent evaporation method. The formulation is aimed to provide sustained release for the required long period with a high margin of safety. We used a blended mixture of Hydroxy Propyl Methyl Cellulose (HPMC) K 100 MCR and Eudragit RL100 polymers to have sustained-release microspheres. The impact of different rpm on Yield, drug encapsulation efficiency, flow properties, and dissolution pattern were appraised. We observed the release of the drug for 10 hours in phosphate buffer (pH 6.8) and evaluated the drug release spectrophotometrically. Our study finds that the release of fexofenadine HCl from the microspheres was significantly increased with drug loading. We found the dosage forms to follow Higuchi release kinetics and Hixson-Crowell release kinetics the most, indicating successful achievement of sustained-release pattern in the dosage form. The change in drug release rate was statistically significant for variation in the stirring rate. We found that 600 rpm was the most optimized stirring rate for preparing microspheres in the emulsion solvent evaporation method.

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Poly(lactic acid)-aspirin microspheres prepared via the traditional and improved solvent evaporation methods and its application performances

Pan

Gao

Wang

et al. 2023

Chinese Journal of Chemical Engineering

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An efficient preparation of porous polymeric microspheres by solvent evaporation in foam phase

Cited by 8 publications

References 34 publications

Online Microfluidic Production of Sustainable Cyrene™-Derived Porous Microparticles

Online Microfluidic Production of Sustainable Cyrene™-Derived Porous Microparticles

Evaluation of the Influence of Stirring Speed on the Release Kinetics of Fexofenadine HCl Polymeric Microspheres

Poly(lactic acid)-aspirin microspheres prepared via the traditional and improved solvent evaporation methods and its application performances

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