An efficient synthesis of 3,4-dihydropyrimidin-2-ones catalyzed by NH2SO3H under ultrasound irradiation

Abstract

The condensation of aldehydes, beta-keto esters and urea catalyzed by NH(2)SO(3)H in ethanol results dihydropyrimidinones in high yields under ultrasound irradiation.

Reformation of 1- (N-11, 21-Epitiopropyl)-4-Phenyl-5-Acetyl-6-Methyl-L, 2,3,4-Tetrahydropyrimidine-2 One With Various Amines

“…On the other hand, they are used as radioprotector preventing radiation rays [2]. Medications such as tifen, aprofen are being successfully implemented at this time in medical clinic as derivatives of aminothiols [3].…”

Synthesis of pyrimidine carboxamide derivatives catalyzed by uranyl nitrate hexa Hydrate with their antibacterial and antioxidant studies

“…Biginelli reaction takes place by mixing different substituted aldehydes, urea or thiourea, and an active 1,3-dicarbonyl compound in combination with different catalytic systems such as AcOH [14], ZrCl 4 [15], Cu(OTf) 2 [16], SiO 2 /H 2 SO 4 [17], La(OTf) 3 [18], CdCl 2 [19], 1-n-butyl-3-methyl imidazolium tetrafluoroborate [20], SiO 2 /NaHSO 4 [21], Pb(NO 3 ) 2 [22], NaCl [23], KSF clay [24], FeCl 3 [25], BiCl 3 [26], ion-exchange resin [27], LiBr [28] [32], Mn(OAc) 3 [33], InBr 3 [ 34], microwave [35][36][37][38] or ultrasound irradiation [39] and solvent-free conditions [40], Co(NO 3 ) 2 .6H 2 O [41], ZnCl 2 /TBAB [42]. In the last two decades microwave mediated reactions have been of great interest in organic synthesis because of their shorter reaction times and high yields of products with good selectivity.…”

An Efficient One-Pot Synthesis of Dihydropyrimidinones Under Solvent-Free Conditions

“…Chem., Vol. 30(1), 355-357 (2014) Although numerous methods are capable of affecting these synthesis has been previously reported [9][10][11][12][13][14][15][16][17][18] . Previously, we have synthesized a number of heterocyclic compounds [19][20][21][22][23][24][25][26][27][28][29][30] .…”