An EGF-Responsive Neural Circuit Couples Insulin Secretion with Nutrition in Drosophila

Meschi, Eleonora; Léopold, Pierre; Delanoue, Rénald

doi:10.1016/j.devcel.2018.11.029

Cited by 51 publications

(48 citation statements)

References 63 publications

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“…In response to a rich amino acid diet and to the activation of TORC1 pathway, the fat body secretes two other factors called GBP1 and GBP2 (Growth Blocking Peptide) that indirectly induce the release of DILP2 and DILP5 by IPCs (Fig. 2 b) [ 36 , 39 ]. Secreted GBP1 binds to its receptor, a transmembrane EGF receptor located on inhibitory neurons (IPC-connecting neurons or ICNs) that synapse with IPCs [ 39 ].…”

Section: Amino Acid Sensing and Secretion Of Hormones By The Fat Bodymentioning

confidence: 99%

“…2 b) [ 36 , 39 ]. Secreted GBP1 binds to its receptor, a transmembrane EGF receptor located on inhibitory neurons (IPC-connecting neurons or ICNs) that synapse with IPCs [ 39 ]. The binding of GBP1 to its receptor removes the inhibition of IPCs by ICNs and thus allows the release of DILPs (Fig.…”

Section: Amino Acid Sensing and Secretion Of Hormones By The Fat Bodymentioning

confidence: 99%

“…The binding of GBP1 to its receptor removes the inhibition of IPCs by ICNs and thus allows the release of DILPs (Fig. 2 b) [ 39 ]. Thus, the intake of food or a rich amino acid diet acts through the fat body and inhibitory neurons to indirectly cause the release of DILPs by IPCs.…”

Section: Amino Acid Sensing and Secretion Of Hormones By The Fat Bodymentioning

confidence: 99%

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Growth regulation by amino acid transporters in Drosophila larvae

Manière

Alves

Berthelot-Grosjean

et al. 2020

Cell. Mol. Life Sci.

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Drosophila larvae need to adapt their metabolism to reach a critical body size to pupate. This process needs food resources and has to be tightly adjusted to control metamorphosis timing and adult size. Nutrients such as amino acids either directly present in the food or obtained via protein digestion play key regulatory roles in controlling metabolism and growth. Amino acids act especially on two organs, the fat body and the brain, to control larval growth, body size developmental timing and pupariation. The expression of specific amino acid transporters in fat body cells, and in the brain through specific neurons and glial cells is essential to activate downstream molecular signaling pathways in response to amino acid levels. In this review, we highlight some of these specific networks dependent on amino acid diet to control DILP levels, and by consequence larval metabolism and growth.

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Section: Amino Acid Sensing and Secretion Of Hormones By The Fat Bodymentioning

confidence: 99%

Section: Amino Acid Sensing and Secretion Of Hormones By The Fat Bodymentioning

confidence: 99%

See 1 more Smart Citation

Growth regulation by amino acid transporters in Drosophila larvae

Manière

Alves

Berthelot-Grosjean

et al. 2020

Cell. Mol. Life Sci.

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“…Conversely, direct incubation of GBP1/2 on starved brains triggers DILPs secretion [31]. GBP1 and GBP2 have been detected circulating in the hemolymph and signals to the IPC through a double inhibition neuronal relay [32]. Finally, along with insulinotropic factors responsive to amino acids, one negative regulator of DILPs production has been identified.…”

Section: The Insulin/igf Signal Controls Juvenile Growthmentioning

confidence: 99%

Growth and Maturation in Development: A Fly’s Perspective

Delanoue

Romero

2020

IJMS

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In mammals like humans, adult fitness is improved due to resource allocation, investing energy in the developmental growth process during the juvenile period, and in reproduction at the adult stage. Therefore, the attainment of their target body height/size co-occurs with the acquisition of maturation, implying a need for coordination between mechanisms that regulate organismal growth and maturation timing. Insects like Drosophila melanogaster also define their adult body size by the end of the juvenile larval period. Recent studies in the fly have shown evolutionary conservation of the regulatory pathways controlling growth and maturation, suggesting the existence of common coordinator mechanisms between them. In this review, we will present an overview of the significant advancements in the coordination mechanisms ensuring developmental robustness in Drosophila. We will include (i) the characterization of feedback mechanisms between maturation and growth hormones, (ii) the recognition of a relaxin-like peptide Dilp8 as a central processor coordinating juvenile regeneration and time of maturation, and (iii) the identification of a novel coordinator mechanism involving the AstA/KISS system.

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“…In addition, GBP1 and CG11395 (GBP2) are secreted from the fat body when TOR activity is high to regulate IPCs (Koyama & Mirth, ). Interestingly, GBPs encode atypical ligands for the fly EGF receptor (EGFR; Meschi, Léopold, & Delanoue, ). In a mechanism reminiscent of Upd2‐Dome signaling, which releases the inhibition of IPCs by GABAergic neurons, activation of EGFR in a subpopulation of inhibitory neurons contacting the IPCs in response to fat body‐derived GBPs allows for insulin secretion.…”

Section: Factors Regulating Ipcs and Dilp Productionmentioning

confidence: 99%

Regulation of insulin and adipokinetic hormone/glucagon production in flies

Ahmad

Perrimon

2019

WIREs Developmental Biology

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Metabolic homeostasis is under strict regulation of humoral factors across various taxa. In particular, insulin and glucagon, referred to in Drosophila as Drosophila insulin‐like peptides (DILPs) and adipokinetic hormone (AKH), respectively, are key hormones that regulate metabolism in most metazoa. While much is known about the regulation of DILPs, the mechanisms regulating AKH/glucagon production is still poorly understood. In this review, we describe the various factors that regulate the production of DILPs and AKH and emphasize the need for future studies to decipher how energy homeostasis is governed in Drosophila. This article is categorized under: Invertebrate Organogenesis > Flies Signaling Pathways > Global Signaling Mechanisms

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An EGF-Responsive Neural Circuit Couples Insulin Secretion with Nutrition in Drosophila

Cited by 51 publications

References 63 publications

Growth regulation by amino acid transporters in Drosophila larvae

Growth regulation by amino acid transporters in Drosophila larvae

Growth and Maturation in Development: A Fly’s Perspective

Regulation of insulin and adipokinetic hormone/glucagon production in flies

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