An elastic second skin

Abstract

We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that can be engineered with specific elasticity, contractility, adhesion, tensile strength and occlusivity. XPL can be topically applied, rapidly curing at the skin interface without the need for heat-or light-mediated activation. In a pilot human study, we examined the performance of a prototype XPL that has a tensile modulus matching normal skin responses at low strain (< 40%), and that withstands elongations exceeding 250%, elastically recoiling with minimal strain-energy loss on repeated deformation. The application of XPL to the herniated lower-eyelid fat pads of 12 subjects resulted in an average 2-grade decrease in herniation appearance in a 5-point severity scale. The XPL platform may offer advanced solutions to compromised skin barrier function, pharmaceutical delivery, and wound dressings.

Mathematical and computational modelling of skin biophysics: a review

“…Understanding the mechanics of wrinkle formation is an essential step towards the development of applications aiming at reducing or removing wrinkles [184] by straightening of wrinkles [185]. For example, Yu et al [184] recently developed a wearable and physico-chemically tuneable polysiloxane-based material that can be topically applied to the skin surface. After curing, the cross-linked polymer layer bonded to the skin effectively straightens wrinkles.…”

A current affair: electrotherapy in wound healing

“…Using a scaffold, such as collagen/gold nanoparticle scaffolds90 or injectable microporous gel scaffolds,91 could provide a biodegradable structure and accelerate cell migration to the wound site, following which an ES can enhance the cellular activity within the scaffold. Specific materials properties can be combined with EST for better aesthetics of the wound during the treatment, by creating a layer on the skin to disguise or “hide” the wound 92. 3D printing is a relatively novel method that enables bespoke therapy and offers an opportunity to 3D print skin scaffolds using the patient’s own cells93 as well as the ability to make bespoke patches 94.…”

New Bioengineering Breakthroughs and Enabling Tools in Regenerative Medicine

“…With this in mind, Yu et al developed a polysiloxane membrane that acts as a “second skin” and restores skin function thanks to its bulk elasticity, contractility, adhesion, and breathability (Fig. 2a) [32]. Material coatings can also provide such tissue-compatibility.…”

“…(Reprinted by permission from Macmillan Publishers Ltd.: Yu B, et al Nat Mater. 2016;15(8):911–8) [32]. b Organoid structures generated using a modular synthetic hydrogel with tuneable matrix elasticity and signaling properties.…”