An electrocardiographic, molecular and biochemical approach to explore the cardioprotective effect of vasopressin and milrinone against phosphide toxicity in rats

Jafari, Abbas Ali; Baghaei, Amir; Solgi, Reza; Baeeri, Maryam; Chamanara, Mohsen; Hassani, Shokoufeh; Gholami, Mahdi; Ostad, Seyed Nasser; Sharifzadeh, Moahmmad; Abdollahi, Mohammad

doi:10.1016/j.fct.2015.02.022

Cited by 38 publications

(42 citation statements)

References 65 publications

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“…The doses of T3, as well as the time interval between drug injection and AlP intoxication (30 min) were chosen according to literature review [16,24,32].…”

Section: Experimental Designmentioning

confidence: 99%

“…ECGs were analyzed by PowerLab system software. The heart rate (HR) and systolic blood pressure (BP) were recorded every 3 minutes by using the tail cuff which was connected to the anesthetized rat tail [6,32].…”

Section: Determination Of Electrocardiogram (Ecg) Parametersmentioning

confidence: 99%

“…of AlP was calculated according to Probit analysis (12 mg/kg) and was used for induction of cardiac toxicity and related events [6,32].…”

Section: Induction Of Alp Intoxicationmentioning

confidence: 99%

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Molecular and biochemical evidences on the protective effects of triiodothyronine against phosphine-induced cardiac and mitochondrial toxicity

et al. 2015

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“…The doses of T3, as well as the time interval between drug injection and AlP intoxication (30 min) were chosen according to literature review [16,24,32].…”

Section: Experimental Designmentioning

confidence: 99%

Section: Determination Of Electrocardiogram (Ecg) Parametersmentioning

confidence: 99%

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Molecular and biochemical evidences on the protective effects of triiodothyronine against phosphine-induced cardiac and mitochondrial toxicity

et al. 2015

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“…Moreover, in animal studies, ALP is dissolved in almond oil before its gavage into the animal's stomach, so it is a great doubt about the efficacy of oils for decreasing ALP absorption in stomach. [8]The authors recommended bicarbonate in the management of ALP poisoning just in cases with pH <7. This suggestion is against other studies and is based on unproven hypotheses.…”

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confidence: 99%

Cardiogenic shock: The main cause of mortality in acute aluminum phosphide poisoning

Mehrpour

Gurjar

2017

Indian Journal of Critical Care Medicine

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On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity

et al. 2017

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Aluminum phosphide (AlP), one of the most commonly used pesticides worldwide, has been the leading cause of self-poisoning mortalities among many Asian countries. The heart is the main organ affected in AlP poisoning. Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart. The present study reveals evidence on the probable protective effects of melatonin on AlP-induced cardiotoxicity in rats. The study groups included a control (almond oil only), ethanol 5% (solvent), sole melatonin (50 mg/kg), AlP (16.7 mg/kg), and 4 AlP + melatonin groups which received 20, 30, 40 and 50 mg/kg of melatonin by intraperitoneal injections following AlP treatment. An electronic cardiovascular monitoring device was used to record the electrocardiographic (ECG) parameters. Heart tissues were studied in terms of oxidative stress biomarkers, mitochondrial complexes activities, ADP/ATP ratio and apoptosis. Abnormal ECG records as well as declined heart rate and blood pressure were found to be related to AlP administration. Based on the results, melatonin was highly effective in controlling AlP-induced changes in the study groups. Significant improvements were observed in the activities of mitochondrial complexes, oxidative stress biomarkers, the activities of caspases 3 and 9, and ADP/ATP ratio following treatment with melatonin at doses of 40 and 50 mg/kg. Our results indicate that melatonin can counteract the AlP-induced oxidative damage in the heart. This is mainly done by maintaining the normal balance of intracellular ATP as well as the prevention of oxidative damage. Further research is warranted to evaluate the possibility of using melatonin as an antidote in AlP poisoning.

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An electrocardiographic, molecular and biochemical approach to explore the cardioprotective effect of vasopressin and milrinone against phosphide toxicity in rats

Cited by 38 publications

References 65 publications

Molecular and biochemical evidences on the protective effects of triiodothyronine against phosphine-induced cardiac and mitochondrial toxicity

Molecular and biochemical evidences on the protective effects of triiodothyronine against phosphine-induced cardiac and mitochondrial toxicity

Cardiogenic shock: The main cause of mortality in acute aluminum phosphide poisoning

On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity

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