An Electrochemical Dopamine Sensor with CMOS Detection Circuit

Zhan, Fenglin; Kuo, Li‐Yaung; Wang, Shiwei; Lu, Michael S.-C.; Wang, Chang; Lin, Chih-Heng; Yang, Yuh‐Shyong

doi:10.1109/icsens.2007.4388686

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…The membrane-sensor would be advantageous to use in bio-applications, where small changes need to be detected in conditions mimicking the in vivo environment, because of its high sensitivity and low detection limit compared to traditional detection methods with detection limits in the nanomolar range. The sensor competes with single-walled carbon nanotubes decorated sensors with a detection limit in the picomolar range [ 1 , 25 – 27 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Membrane-Based Electrochemical Sensor for Real-Time Bio-Applications

Alatraktchi

Bakmand

Dimaki

et al. 2014

Sensors

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This article presents a novel membrane-based sensor for real-time electrochemical investigations of cellular- or tissue cultures. The membrane sensor enables recording of electrical signals from a cell culture without any signal dilution, thus avoiding loss of sensitivity. Moreover, the porosity of the membrane provides optimal culturing conditions similar to existing culturing techniques allowing more efficient nutrient uptake and molecule release. The patterned sensor electrodes were fabricated on a porous membrane by electron-beam evaporation. The electrochemical performance of the membrane electrodes was characterized by cyclic voltammetry and chronoamperometry, and the detection of synthetic dopamine was demonstrated down to a concentration of 3.1 pM. Furthermore, to present the membrane-sensor functionality the dopamine release from cultured PC12 cells was successfully measured. The PC12 cells culturing experiments showed that the membrane-sensor was suitable as a cell culturing substrate for bio-applications. Real-time measurements of dopamine exocytosis in cell cultures were performed, where the transmitter release was recorded at the point of release. The developed membrane-sensor provides a new functionality to the standard culturing methods, enabling sensitive continuous in vitro monitoring and closely mimicking the in vivo conditions.

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Section: Resultsmentioning

confidence: 99%

Novel Membrane-Based Electrochemical Sensor for Real-Time Bio-Applications

Alatraktchi

Bakmand

Dimaki

et al. 2014

Sensors

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“…It has been shown that a few nanometer thickness of titanium film is capable of providing a good ground for Au film growth [51]. The Au layer deposited using photolithography method provides better adhesion for post processing of the substrates due to high purity of the metals deposited [52]- [54]. The inert Au layer deposited have also been employed for electrochemical detection and Table I summarizes the electrochemical sensors fabricated based on Au films deposited on the working electrodes.…”

Section: B Photolithography Methods For Au Film Deposition On Al Elec...mentioning

confidence: 99%

Advances in Nanomaterials Integration in CMOS-Based Electrochemical Sensors: A Review

Gill¹,

Ghoreishizadeh²

2023

IEEE Sensors J.

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“…Furthermore, performance was increased signifi cantly by scaling the inter-electrode distance down to sizes of 30 nm in IDAs or below 4 nm in a single nanogap (Ueno et al 2005. New developments aim for advanced on-chip signal amplifi cation or high-throughput processing based on addressable microarrays , Takeda et al 2011, Zhu et al 2011 and complementary metal oxide semiconductor (CMOS) technology (Zhu and Ahn 2006, Zhan et al 2007, Huang and Lu 2010.…”

Section: Interdigitated Arraysmentioning

confidence: 99%

On-chip redox cycling techniques for electrochemical detection

Kätelhön¹,

Wolfrum²

2012

Reviews in Analytical Chemistry

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During the last two decades, redox cycling techniques have evolved as a promising technique for the electrochemical detection of molecules that can undergo subsequent redox reactions. In particular, chip-based techniques received growing attention due to the option of parallel fabrication and easy integration into lab-on-a-chip devices. In here, we provide a review on current implementations of on-chip redox cycling sensors. Advantages and limitations of various approaches are discussed with regard to their fabrication process and performance.

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An Electrochemical Dopamine Sensor with CMOS Detection Circuit

Cited by 4 publications

References 29 publications

Novel Membrane-Based Electrochemical Sensor for Real-Time Bio-Applications

Novel Membrane-Based Electrochemical Sensor for Real-Time Bio-Applications

Advances in Nanomaterials Integration in CMOS-Based Electrochemical Sensors: A Review

On-chip redox cycling techniques for electrochemical detection

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