An electron‐microscope study of the effects of lysolecithin on BP8 ascites‐tumour cells and phagocytes of mice, compared with the effects of a specific anti‐tumour serum plus complement

Lysophosphatidylcholine (lysolecithin) and its synthetic analogues. Immunemodulating and other biologic effects

“…It is highly surface-active (44.3 dyn/cm) [4] and, therefore, potentially cytotoxic if incubated with cells in s e r u m -o r plasma free-media [4,30,31,33,44,72,76]. Addition in sublytic amounts, however, stimulates phagocytosis [16,20,80], changes the surface properties of erythrocytes [36], increases the Concanavalin-A (Con-A)-induced agglutination oferythrocytes [75], and may be used as a cell-fusing agent [58]. Furthermore, it has been claimed to be involved in hypersensitivity [38,70] and inflammatory reactions [17].…”