An electrophoretic comparison of the venoms of a colubrid and various viperid snakes from Turkey and Cyprus, with some taxonomic and phylogenetic implications

Arıkan, Hüseyin; Göçmen, Bayram; Mermer, Ahmet; Bahar, Hasan

doi:10.11646/zootaxa.1038.1.1

Cited by 12 publications

(3 citation statements)

References 14 publications

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“…The Ottoman Viper, Montivipera xanthina (Gray, 1849), an almost endemic species to Turkey, is known from the Central, Southern and Western Anatolia as well as some adjacent islands of Greece with vertical distribution to 2,000 m (Arikan et al 2005;Samy et al 2007;Göçmen et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ottoman Viper (Montivipera xanthina (Gray, 1849)) Venom on Various Cancer Cells and on Microorganisms

et al. 2013

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Cytotoxic and antimicrobial effects of Montivipera xanthina venom against LNCaP, MCF-7, HT-29, Saos-2, Hep3B, Vero cells and antimicrobial activity against selected bacterial and fungal species: Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, E. coli O157H7, Enterococcus faecalis 29212, Enterococcus faecium DSM 13590, Staphylococcus epidermidis ATCC 12228, S. typhimirium CCM 5445, Proteus vulgaris ATCC 6957 and Candida albicans ATCC 10239 were studied for evaluating the potential medical benefit of this snake venom. Cytotoxicity of venom was determined using MTT assay. Snake venom cytotoxicity was expressed as the venom dose that killed 50 % of the cells (IC50). The antimicrobial activity of venom was studied by minimal inhibitory concentration (MIC) and disc diffusion assay. MIC was determined using broth dilution method. The estimated IC50 values of venom varied from 3.8 to 12.7 or from 1.9 to 7.2 μg/ml after treatment with crude venom for 24 or 48 h for LNCaP, MCF-7, HT-29 and Saos-2 cells. There was no observable cytotoxic effect on Hep3B and Vero cells. Venom exhibited the most potent activity against C. albicans (MIC, 7.8 μg/ml and minimal fungicidal concentration, 62.5 μg/ml) and S. aureus (MIC, 31.25 μg/ml). This study is the first report showing the potential of M. xanthina venom as an alternative therapeutic approach due to its cytotoxic and antimicrobial effects.

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Section: Introductionmentioning

confidence: 99%

Effect of Ottoman Viper (Montivipera xanthina (Gray, 1849)) Venom on Various Cancer Cells and on Microorganisms

et al. 2013

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“…Studies conducted in Anatolia have reported that, 15 venomous snake species (14 belonging to the family Viperidae) live in Anatolia [9]. Most of the venomous snake species in our country are the members of familia Viperidae [3].…”

Section: Discussionmentioning

confidence: 99%

Management of Poisonous Snake Bites: Analysis of 29 Cases

et al. 2018

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Objectives:The objective of this retrospective study is to provide contribution for management of the poisonous snake bites by comparison results of this study with the literature data. Patients and Methods:This study retrospectively analyzed the demographic and epidemiologic characteristics of 40 patients who presented due to snake bites. 29 patients were included in this study. Patients' age, sex, month of admission, duration of follow-up in the emergency room, laboratory outcomes, the regions of snake bite, number of the bites, local and systemic symptoms, and treatment received were assessed. Patients aged under 18 years were excluded from the study. Also patients were excluded if the snakes were not seen after the patients were bitten or if they developed no local or systemic symptoms within four hours after the bite. In addition, patients in whom adequate data could not be obtained were also excluded from the study. Results:Out of the 29 patients included in this study, 15 (51.7%) were females. When the patients were examined according to local and systemic findings; local symptoms were observed in 18 patients (62.1%) and systemic symptoms in 11 patients (37.9%). There was a positive correlation between elevated ALP and diffuse edema in the bite area and hypotension findings. When durations of hospitalization were analyzed, the mean duration of hospitalization was 2.3±1.5 days. Conclusion:We believe that, symptomatic and supportive treatment could be sufficient in majority of the patients with snake bites in our region, and a low dose antiserum therapy would be reasonable when antiserum is needed.

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“…Diff ering from other Vipera species, Macrovipera has fi nely divided supraocular plates. It has a subspecies endemic to Cyprus: Macrovipera lebetina lebetina (Arıkan et al, 2005 ;Göçmen et al, 2006 ). According to Baran ( 1976 ) and Başoğlu and Baran (1980), on the nearest mainland, Anatolia, lives Macrovipera lebetina obtusa .…”

Section: Viperidaementioning

confidence: 99%

Taxonomic notes on the snakes of Northern Cyprus, with observations on their morphologies and ecologies

et al. 2009

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A total of 66 specimens belonging to eleven snake species, some of which were collected during the field studies of 17-31 July and 3-25 September 2003, and some others which have been previously collected and all have been deposited into the collection of ZDEU (Zoology Dept. Ege University), were evaluated taxonomically. 25 of the specimens belonged to Typhlopidae, 37 to Colubridae, three to Viperidae and one to Boidae. These specimens were evaluated from the points of view of pholidosis, pattern and coloration and morphological measurements. Some biological and ecological information were also given with the brief geological history of eastern Mediterranean region.

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An electrophoretic comparison of the venoms of a colubrid and various viperid snakes from Turkey and Cyprus, with some taxonomic and phylogenetic implications

Cited by 12 publications

References 14 publications

Effect of Ottoman Viper (Montivipera xanthina (Gray, 1849)) Venom on Various Cancer Cells and on Microorganisms

Effect of Ottoman Viper (Montivipera xanthina (Gray, 1849)) Venom on Various Cancer Cells and on Microorganisms

Management of Poisonous Snake Bites: Analysis of 29 Cases

Taxonomic notes on the snakes of Northern Cyprus, with observations on their morphologies and ecologies

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