An electrostatic finite element analysis of the electrospinning process of bilayer constructs using a parallel-plate collector

Molina, Maria I. Echeverria; Komvopoulos, K.

doi:10.1016/j.matlet.2022.131649

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…In the vertical and horizontal directions of the spinneret, the electric field intensity gets smaller farther away from the spinneret. According to the force analysis in point A in Figure 1a , when the electric field force ( P E ) acting on the spinning solution surface was greater than the solution surface tension ( P s ), unstable fluctuation on the free surface of solution easily occurs, thus significantly increasing the probability of multijet formation [ 25 – 26 ].…”

Section: Resultsmentioning

confidence: 99%

Batch preparation of nanofibers containing nanoparticles by an electrospinning device with multiple air inlets

Wei¹,

Ye²,

Ahmed³

et al. 2023

Beilstein J. Nanotechnol.

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With the increasing application of electrospun nanofibers, the batch preparation of high-performance functional nanofibers containing nanoparticles has become a research hotspot. As the distribution uniformity of nanoparticles in functional nanofibers has a great impact on their performance, an electrospinning device with multiple air inlets, which has a copper porous spinneret, is proposed to obtain functional nanofibers with higher yield and more uniform distribution of nanoparticles. The mechanism of batch preparation of functional nanofibers containing ZnO nanoparticles by the device was studied through experiments and theoretical analysis. The experimental data are in good agreement with the theoretical analysis results, which showed that under the appropriate voltage (50 kV) and air flow (50 m3/h), the device could keep ZnO nanoparticles contained in the spinning solution evenly dispersed during the spinning process, thus obtaining functional nanofibers with more uniform distribution of ZnO nanoparticles, whose quality and yield were higher than those prepared by other high-yield electrospinning devices.

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Section: Resultsmentioning

confidence: 99%

Batch preparation of nanofibers containing nanoparticles by an electrospinning device with multiple air inlets

Wei¹,

Ye²,

Ahmed³

et al. 2023

Beilstein J. Nanotechnol.

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“…Fibrous scaffolds with a thickness ~200 µm were fabricated with an electrospinning setup equipped with a parallel disk collector, described in detail elsewhere [20,36,37]. The PCL solution was pumped at a rate of 0.8 mL/h through a 22 G flat-tip needle affixed 10 cm above the collector axis.…”

Section: Scaffold Fabricationmentioning

confidence: 99%

“…The collector design entails two parallel aluminum plates attached to a 1.5-cm-diameter shaft and placed at a lateral distance of 1.5 cm from each other. This collector geometry yields bilayer scaffolds with morphologies characterized by fibers mostly aligned between the parallel plates (bottom surface) and randomly oriented fibers (top surface) [36,37].…”

Section: Scaffold Fabricationmentioning

confidence: 99%

Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering

Molina¹,

Chen²,

Martinez³

et al. 2022

Materials

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After decades of research, fully functional skin regeneration is still a challenge. Skin is a multilayered complex organ exhibiting a cascading healing process affected by various mechanisms. Specifically, nutrients, oxygen, and biochemical signals can lead to specific cell behavior, ultimately conducive to the formation of high-quality tissue. This biomolecular exchange can be tuned through scaffold engineering, one of the leading fields in skin substitutes and equivalents. The principal objective of this investigation was the design, fabrication, and evaluation of a new class of three-dimensional fibrous scaffolds consisting of poly(ε-caprolactone) (PCL)/calcium alginate (CA), with the goal to induce keratinocyte differentiation through the action of calcium leaching. Scaffolds fabricated by electrospinning using a PCL/sodium alginate solution were treated by immersion in a calcium chloride solution to replace alginate-linked sodium ions by calcium ions. This treatment not only provided ion replacement, but also induced fiber crosslinking. The scaffold morphology was examined by scanning electron microscopy and systematically assessed by measurements of the pore size and the diameter, alignment, and crosslinking of the fibers. The hydrophilicity of the scaffolds was quantified by contact angle measurements and was correlated to the augmentation of cell attachment in the presence of CA. The in vitro performance of the scaffolds was investigated by seeding and staining fibroblasts and keratinocytes and using differentiation markers to detect the evolution of basal, spinous, and granular keratinocytes. The results of this study illuminate the potential of the PCL/CA scaffolds for tissue engineering and suggest that calcium leaching out from the scaffolds might have contributed to the development of a desirable biological environment for the attachment, proliferation, and differentiation of the main skin cells (i.e., fibroblasts and keratinocytes).

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In vitro degradation of fibrous bilayer poly-L-lactic acid scaffolds

Molina,

Komvopoulos

2023

Journal of Biomechanics

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An electrostatic finite element analysis of the electrospinning process of bilayer constructs using a parallel-plate collector

Cited by 3 publications

References 10 publications

Batch preparation of nanofibers containing nanoparticles by an electrospinning device with multiple air inlets

Batch preparation of nanofibers containing nanoparticles by an electrospinning device with multiple air inlets

Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering

In vitro degradation of fibrous bilayer poly-L-lactic acid scaffolds

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