An embarrassment of niches: the many covalent modifications of histones in transcriptional regulation

Berger, Shelley L.

doi:10.1038/sj.onc.1204324

Cited by 99 publications

(63 citation statements)

References 61 publications

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“…It has recently become apparent that core histones may also be modified not only by acetylation but also by methylation, phosphorylation, and ubiquitination and that these modifications may regulate gene transcription (32). Methylation of histones, particularly histone-3, by histone methyltransferases, results in gene suppression (33).…”

Section: Other Histone Modificationsmentioning

confidence: 99%

How Do Corticosteroids Work in Asthma?

2003

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Section: Other Histone Modificationsmentioning

confidence: 99%

How Do Corticosteroids Work in Asthma?

2003

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“…Methylation of DNA is essential for mammalian development (2) and is associated with gene silencing in conjunction with histone core modifications probably through chromatin remodeling (3)(4)(5)(6)(7)(8). The level of DNA methylation of bulk genome changes during mammalian embryogenesis.…”

mentioning

confidence: 99%

DNA Methylation-dependent Epigenetic Regulation of Dimethylarginine Dimethylaminohydrolase 2 Gene in Trophoblast Cell Lineage

Tomikawa

Fukatsu

Tanaka

et al. 2006

Journal of Biological Chemistry

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Trophoblast cell lineage is established through the first cellular differentiation in mammalian embryogenesis, and its developmental potential is restricted to the extraembryonic tissues contributing solely to the placenta. Several lines of evidence suggest a relative lack of importance of DNA methylation in gene regulation in the extraembryonic tissues when compared with embryonic ones. Here we analyzed the dynamics of epigenetic status in the upstream region of mouse Ddah2 gene, which was found to be specifically repressed in a stem cell population of trophoblast cell lineage. We found a tissue-dependent differentially methylated region in the regulatory region of the Ddah2 gene. This region was hypermethylated in trophoblast stem cells and was hypomethylated in differentiated cells both in vivo and in vitro. This change was well correlated with Ddah2 expression. In addition, in vitro methylation confined to the differentially methylated region was sufficient to repress promoter activity in the reporter assay. Furthermore, a repressive pattern of histone modifications was formed around the differentially methylated region in undifferentiated trophoblast stem cells with repressed Ddah2. Our data suggest that DNA methylation-mediated chromatin remodeling is involved in the regulation of the Ddah2 gene expression and thus is important even in trophoblast cell lineage.

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“…Alteration of chromatin by covalent modification of histone proteins is central to the regulation of gene expression in eukaryotic organisms (1)(2)(3). Acetylation of histones H3 and H4 are the best characterized covalent modifications of histones and have wide ranging effects on gene expression (1)(2)(3)(4).…”

mentioning

confidence: 99%

“…Acetylation of histones H3 and H4 are the best characterized covalent modifications of histones and have wide ranging effects on gene expression (1)(2)(3)(4). Histone phosphorylation is important for transcriptional activation, condensation of chromosomes during mitosis and meiosis, and regulation of cell division (5,6).…”

mentioning

confidence: 99%

COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression

Krogan

Dover

Khorrami

et al. 2002

Journal of Biological Chemistry

381

347

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The trithorax (Trx) family of proteins is required for maintaining a specific pattern of gene expression in some organisms. Recently we reported the isolation and characterization of COMPASS, a multiprotein complex that includes the Trx-related protein Set1 of the yeast Saccharomyces cerevisiae. Here we report that COM-PASS catalyzes methylation of the fourth lysine of histone H3 in vitro. Set1 and several other components of COMPASS are also required for histone H3 methylation in vivo and for transcriptional silencing of a gene located near a chromosome telomere.

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An embarrassment of niches: the many covalent modifications of histones in transcriptional regulation

Cited by 99 publications

References 61 publications

How Do Corticosteroids Work in Asthma?

How Do Corticosteroids Work in Asthma?

DNA Methylation-dependent Epigenetic Regulation of Dimethylarginine Dimethylaminohydrolase 2 Gene in Trophoblast Cell Lineage

COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression

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