An Emerging Problem: Methamphetamine Abuse among Treatment Seeking Youth

Gonzales, Rachel; Ang, Alfonso; McCann, Michael; Rawson, Richard A.

doi:10.1080/08897070802093312

Cited by 47 publications

(28 citation statements)

References 30 publications

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“…For example, adolescent girls are more likely to use methamphetamine than boys (Gonzales, Ang, McCann, & Rawson, 2008;Rawson, Gonzales, McCann, & Obert, 2005), and, according to a recent report published by the ONDCP, more than 12% of adolescent girls living in Nevada reported a history of methamphetamine use (ONDCP, 2008). In fact, the weight loss side effects of stimulants like methamphetamine are so strong that they are sometimes used to treat severe exogenous obesity in forms like Desoxyn (methamphetamine hydrochloride; see Food and Drug Administration [FDA], 2007).…”

Section: Western Culture Weight-loss and Drug Use In Womenmentioning

confidence: 92%

A gender-specific approach to improving substance abuse treatment for women: The Healthy Steps to Freedom program

Lindsay

Warren

Velasquez

et al. 2012

Journal of Substance Abuse Treatment

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Section: Western Culture Weight-loss and Drug Use In Womenmentioning

confidence: 92%

A gender-specific approach to improving substance abuse treatment for women: The Healthy Steps to Freedom program

Lindsay

Warren

Velasquez

et al. 2012

Journal of Substance Abuse Treatment

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“…While rates of adolescent MA use are relatively low compared to other drugs of abuse, studies suggest the rates of adolescents seeking treatment for MA abuse increased in the early 2000s [4, 5]. The behavioral, cognitive, and neurobiological effects of MA may differ in adolescents compared to adults, as adolescence is a dynamic period of brain and behavioral maturation [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice

Buck

Morris

Weber

et al. 2017

Behavioural Brain Research

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The neurotoxic effects of methamphetamine (MA) exposure in the developing and adult brain can lead to behavioral alterations and cognitive deficits in adults. Previous increases in the rates of adolescent MA use necessitate that we understand the behavioral and cognitive effects of MA exposure during adolescence on the adolescent brain. Adolescents using MA exhibit high rates of nicotine (NIC) use, but the effects of concurrent MA and NIC in the adolescent brain have not been examined, and it is unknown if NIC mediates any of the effects of MA in the adolescent. In this study, the long-term effects of a neurotoxic dose of MA with or without NIC exposure during early adolescence (postnatal day 30-31) were examined later in adolescence (postnatal day 41-50) in male C57BL/6J mice. Effects on behavioral performance in the open field, Porsolt forced swim test, and conditioned place preference test, and cognitive performance in the novel object recognition test and Morris water maze were assessed. Additionally, the effects of MA and/or NIC on levels of microtubule associated-2 (MAP-2) protein in the nucleus accumbens and plasma corticosterone were examined. MA and NIC exposure during early adolescence separately decreased anxiety-like behavior in the open field test, which was not seen following co-administration of MA/NIC. There was no significant effect of early adolescent MA and/or NIC exposure on the intensity of MAP-2 immunoreactivity in the nucleus accumbens or on plasma corticosterone levels. These results show that early adolescent MA and NIC exposure separately decrease anxiety-like behavior in the open field, and that concurrent MA and NIC exposure does not induce the same behavioral change as either drug alone.

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“…Some adolescents begin using drugs during this time and it has been reported that adolescent-onset users transition to dependence more readily than adults (Chen et al 2009) and have poorer treatment outcomes (Gonzales et al 2008;Chen et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes

Hankosky¹,

Westbrook²,

Haake³

et al. 2017

Preprint

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RATIONALE: Adolescence is a period of considerable development of brain and behavior and is the time during which most drug use is initiated. OBJECTIVE: Age-dependent differences in motivated behaviors may be one of the factors that contribute to heightened vulnerability to developing substance use disorders, so we sought to compare age differences in methamphetamine (METH) and saccharin seeking. METHODS: Beginning during adolescence or adulthood, male and female Sprague-Dawley rats were trained to self-administer 0.1% saccharin (via liquid dipper cup) or intravenous METH at one of three doses (0.02, 0.05, 0.08 mg/kg/inf) under increasing fixed ratio schedules of reinforcement. Subsequently, responding for METH (0.02, 0.05, 0.08 or 0.1 mg/kg/inf) under progressive ratio response requirements was assessed in rats that acquired METH self-administration at the highest dose (0.08 mg/kg/inf). RESULTS:We found that adult-onset rats acquired METH self-administration more readily and exhibited higher motivation compared to adolescent-onset rats, although there were no differences in METH intake during acquisition. Adult rats also acquired saccharin selfadministration more readily, but in contrast to METH, there were age and sex differences in saccharin intake driven by high levels of responding in adult females. CONCLUSIONS: These findings challenge the prevailing notion that adolescents are hypersensitive to reward and instead raise questions about the potential role of methodological factors on which rodent studies often differ.

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An Emerging Problem: Methamphetamine Abuse among Treatment Seeking Youth

Cited by 47 publications

References 30 publications

A gender-specific approach to improving substance abuse treatment for women: The Healthy Steps to Freedom program

A gender-specific approach to improving substance abuse treatment for women: The Healthy Steps to Freedom program

Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice

Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes

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