Novel coronavirus outbreak in 2019, the production of global epidemic prevention products can not keep up with the needs of society, and the defect of human resource management of imported animal epidemic prevention products processing enterprises has become an urgent need to resolve. The purpose of this paper is to analyze some defects of human resource management in the processing enterprises of imported animal epidemic prevention products, as well as the management methods to be improved, so as to give the management opinions of human resource and realize the production of enterprises in Colleges and universities. Based on the theory of human resource investment and the theory of human resource motivation, this paper takes m enterprise in Shanghai as the research object, and analyzes the employees' satisfaction with performance appraisal and evaluation system, salary management and incentive management. The results show that, like most domestic enterprises, human resource training of imported animal epidemic prevention products processing enterprises only stays at the primary stage, with a single way and content, which is very inconsistent with the current development level of enterprises. First of all, the enterprise leadership must change their thinking, pay attention to the spiritual needs of employees, pay attention to the long-term career development planning of employees, establish and improve the talent training mechanism, truly improve the skills of employees through training, correct the attitude of employees, and support the development of employees. Let employees realize that benefits are not only reflected in money, but also feel the importance attached by the company to them, and understand that training is the best benefit provided by the company. In order to stimulate their creativity and potential, improve business performance, enhance the competitiveness of enterprises.