The TIME-IGGCAS (Theoretical Ionospheric Model of the Earth in Institute of Geology and Geophysics, Chinese Academy of Sciences) has been developed recently on the basis of previous works. To test its validity, we have made comparisons of model results with other typical empirical ionospheric models (IRI, NeQuick-ITUR, and TItheridge temperature models) and multi-observations (GPS, Ionosondes, Topex, DMSP, FORMOSAT, and CHAMP) in this paper. Several conclusions are obtained from our comparisons. The modeled electron density and electron and ion temperatures are quantitatively in good agreement with those of empirical models and observations. TIME-IGGCAS can model the electron density variations versus several factors such as local time, latitude, and season very well and can reproduce most anomalistic features of ionosphere including equatorial anomaly, winter anomaly, and semiannual anomaly. These results imply a good base for the development of ionospheric data assimilation model in the future. TIME-IGGCAS underestimates electron temperature and overestimates ion temperature in comparison with either empirical models or observations. The model results have relatively large deviations near sunrise time and sunset time and at the low altitudes. These results give us a reference to improve the model and enhance its performance in the future. ionosphere, theoretical model, empirical model, satellite observation, relative deviation Recently, we have developed a middle and low latitude theoretical ionospheric model on the basis of previous works, named Theoretical Ionospheric Model of the Earth in Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME-IGGCAS) [1][2][3][4][5][6][7] . In comparison with previous models, we assimilate advantages of every model mentioned. For example, the equations are also solved along the magnetic lines as most models do, we also combine the Eulerian and Lagrangian