An enduring in vitro wound healing phase recipient by bioactive glass-graphene oxide nanocomposites

Abstract

Bioactive glass (BG) is an interesting topic in soft tissue engineering because of its biocompatibility and bonding potential to increase fibroblast cell proliferation, synthesize growth factors, and stimulate granulation tissue development. The proposed BG with and without sodium (Na), prepared by the sol–gel method, is employed in wound healing studies. The BG/graphene oxide (GO) and BG (Na-free)/GO nanocomposites were investigated against fibroblast L929 cells in vitro; the 45S5 BG nanocomposites exhibited desired cell viability (80%), cell proliferation (30%), cell migration (25%), metabolic activity, and wound contraction due to extracellular matrix (ECM) production and enhanced protein release by fibroblast cells. Additionally, the antioxidant assays for BG, BG (Na-free), GO, and BG/GO, BG (Na-free)/GO were evaluated for effective wound healing properties. The results showed decreased inflammation sites in the wound area, assessed by the (2,2-diphenyl-1-picryl-hydrazyl-hydrate) (DPPH) assay with ~ 80% radical scavenging activity, confirming their anti-inflammatory and improved wound healing properties.

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

“…The second approach to administering BG to skin wounds involved formulating them into fibers, scaffolds, and composite materials. ,,− ,,− ,,,− Due to their physical characteristics, manipulation of melt-derived BGs presented challenges in the translation to soft tissue applications. Morphologically tailored porous sol–gel BGs provide a means to overcome these challenges.…”

Devitrite (Na2Ca3Si6O16) phase dominated nanostructured 45S5 bioactive glass: exploring its structural and biological properties

“…This mineralization mechanism is referred to as extracellular matrix (ECM) production or metastatic categorization in necrotic cells, specifically in hard tissues. To investigate the physiological and chemical pathway of mineral deposition on the surface and assess the ECMforming potential of 45S5 BGs, they were submerged in a solution called hanks salt for a period of 21 d [34]. Subsequently, the samples were collected at predetermined intervals (1st, 3rd, 7th, and 14th day) and subjected to drying before further analysis.…”

Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

“… 20 The formulation of nanocomposite hydrogels represents a symphony of scientific disciplines, each contributing a unique note to the harmonious composition of these materials. 21 At its core, the design process aims to orchestrate the perfect blend of nanoparticle characteristics and hydrogel properties, yielding a biomaterial that transcends the capabilities of its components. The formulation and design of nanocomposite hydrogels depend on several factors, such as the type and concentration of nanomaterials, the polymer composition and crosslinking method, the solvent and pH conditions, and the desired application.…”