An Enzyme‐Responsive Polymeric Superamphiphile

Supramolecular Peptide Amphiphile Vesicles through Host–Guest Complexation

“…In an aqueous environment, these peptide amphiphiles undergo self-assembly into structures such as vesicles, both spherical and cylindrical micelles or nanotubes, and have been successfully applied in the biomedical sciences for biomaterial conjugation [4] and as bioactive scaffolds for tissue engineering. [9][10][11][12][13][14][15] Cucurbit[n]urils (CB[n]) are a family of macrocyclic hosts known to form inclusion complexes with selectivity and high binding affinity in aqueous media. A supramolecular approach to form the peptide amphiphile by connecting two building blocks through a non-covalent interaction would represent a major advance, especially in designing stimuliresponsive systems capable of being targeted by specific triggers.…”

Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

“…To achieve this goal, continuous efforts have been dedicated to the development of stimuli-responsive nanoplatforms. [2] Environmental stimuli that were exploited include pH, [3] temperature, [4] enzymatic expression, [5] redox reaction, [6] and light. [7] Among these activating signals, pH triggers belong to the most extensively studied stimuli based on two types of differences in pH: a) pathological (e.g.…”

Enzyme-responsive nanomaterials for controlled drug delivery

“…In the past years, a number of nanoscale materials have been employed for the design of enzyme-responsive drug delivery systems including polymer materials, 28–30 phospholipids 31, 32 and inorganic materials. 33 The integration of nanomaterials with enzymatic responses can endow the formulations with bio-specificity and selectivity, allowing for the promising applications in diverse fields.…”