An epidemiologic study of mild cognitive impairment in Kolkata, India

Das, Shyamal Kumar; Bose, Paramita; Biswas, Atanu; Dutt, Aparna; Banerjee, Tapas Kumar; Hazra, Avijit; Raut, Deepak Kashinath; Chaudhuri, Arijit; Roy, Trishit

doi:10.1212/01.wnl.0000264424.76759.e6

Cited by 142 publications

(121 citation statements)

References 34 publications

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“…Whereas, Shaji et al and Das et al reported hypertension and Diabetes Mellitus as a risk factors for dementia. 4,13 Reduced hearing [aOR 4.67 (1.15-18.91)] was a significant predictive factor of dementia in our study. Even though no causal link has been established between hearing loss and dementia, many epidemiological studies have shown hearing loss as a risk factor for developing dementia.…”

Section: Independent Risk Factors Of Dementiasupporting

confidence: 53%

“…Studies conducted in Kerala, Tamil Nadu and other parts of Northern India also reported increasing age as a nonmodifiable risk factor of dementia. 4,13,[16][17][18][19][20] Zhang et al reported the first time regarding the strong association of low education with dementia. 21 Similar association was also noted in the present study [OR 7.40 (2.70-20.34)].…”

Section: Independent Risk Factors Of Dementiamentioning

confidence: 99%

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Risk factors of dementia: a comparative study among the geriatric age group in Ernakulam, Southern India

Lalu

Vijayakumar

George

et al. 2018

Int J Community Med Public Health

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Background: Dementia is the global deterioration of the individual’s intellectual, emotional and cognitive faculties in a state of normal consciousness. Dementia impacts personal, family and societal life. It reduces life span, induces caregiver’s strain at family level and over utilizes health care facility. This study was aimed at describing the risk factors attributing to dementing disorders for developing preventive measures to slow down the incidence of dementia. Methods: The study was conducted in geriatrics OPD of a tertiary hospital in South India. A total of 50 dementia patients and 50 controls aged more than 65 years were selected for the study in a period of 6 months. A semi-structured questionnaire was used to collect data. Results: 40% in the age group of 65-74 years, 61% in the age group of 75-84 years and 63.6% in the age >85 years had dementia. 43.5% of males and 55.5% of females had dementia. Multivariate analysis was done to find out the independent predictors of dementia. Among the morbidities dyslipidemia 3.93 (1.12-13.87) and COPD/bronchial asthma 4.57 (1.02-20.55), less than 5 days of fruit consumption 14.98 (38-59), hearing loss 4.67 (1.15-18.91) were found to be independent risk factors for dementia. Living alone was found to be a protective factor 0.029 (0.003-0.29). Conclusions: Our study reported various risk factors of dementia that were in agreement with findings from other studies conducted in India. Avoidable risk factors such as living alone, fruit intake and control of comorbidities such as hypertension, dyslipidemia and COPD/bronchial asthma needs more attention in old age group.

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Section: Independent Risk Factors Of Dementiasupporting

confidence: 53%

Section: Independent Risk Factors Of Dementiamentioning

confidence: 99%

Risk factors of dementia: a comparative study among the geriatric age group in Ernakulam, Southern India

Lalu

Vijayakumar

George

et al. 2018

Int J Community Med Public Health

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“…Available evidence indicates that the prevalence of MCI ranges from 7.7% to 42.0% depending on the age groups under consideration, the country where the study was conducted, and the diagnostic criteria used to make the diagnosis [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] (Table 1). The data from these studies indicate that MCI commonly occurs in older adults across different cultures, races, and ethnicities.…”

Section: Epidemiologymentioning

confidence: 99%

Mild cognitive impairment: A comprehensive review

2015

Healthy Aging Res

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Mild cognitive impairment (MCI) represents an intermediate stage between normal cognitive changes associated with aging and dementia. Individuals with MCI have been identified as having a faster rate of progression to dementias. Risk factors for progression include greater cognitive deficits at baseline, ApoE4 carrier status, brain volume changes, cerebrospinal fluid (CSF) changes, and the presence of behavioral and psychological symptoms. Refinements in the diagnostic criteria for MCI and the identification of biomarkers to predict the progression to dementias have resulted in the appropriate diagnosis of this condition being made and the development of possible prevention and treatment strategies. Available data indicate that cognitive and physical training appears to slow the progression of the disease process. Studies of pharmacotherapeutic agents do not indicate benefit for cholinesterase inhibitors, the anti-inflammatory drug rofecoxib, or antioxidants in slowing the progression of MCI to dementias.

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“…43 Moreover, amyloid-b deposition --a pathological hallmark of AD which can now be measured in vivo with amyloid imaging techniques --has been associated with vascular risk factors such as physical inactivity, higher plasma concentrations of cortisol, and hypertension. [44][45][46] The diagnosis of MCI has also been associated with several CVRFs; these include hypertension, 47,48 diabetes, 49,50 and increased cholesterol levels. 51,52 A recent large neuropathological study (5,715 cases) found that vascular pathology is more prevalent in patients with AD than in those with frontotemporal lobar degeneration, dementia with Lewy bodies, or Parkinson's disease dementia.…”

Section: Cardiovascular Risk Factors and Cognitive Declinementioning

confidence: 99%

The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies

Ferreira

Tamashiro-Duran

Squarzoni

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: To review functional neuroimaging studies about the relationship between cardiovascular risk factors (CVRFs), Alzheimer's disease (AD), and mild cognitive impairment (MCI). Methods: We performed a comprehensive literature search to identify articles in the neuroimaging field addressing CVRF in AD and MCI. We included studies that used positron emission tomography (PET), single photon emission computerized tomography (SPECT), or functional magnetic resonance imaging (fMRI). Results: CVRFs have been considered risk factors for cognitive decline, MCI, and AD. Patterns of AD-like changes in brain function have been found in association with several CVRFs (both regarding individual risk factors and also composite CVRF measures). In vivo assessment of AD-related pathology with amyloid imaging techniques provided further evidence linking CVRFs and AD, but there is still limited information resulting from this new technology. Conclusion: There is a large body of evidence from functional neuroimaging studies supporting the hypothesis that CVRFs may play a causal role in the pathophysiology of AD. A major limitation of most studies is their cross-sectional design; future longitudinal studies using multiple imaging modalities are expected to better document changes in CVRF-related brain function patterns and provide a clearer picture of the complex relationship between aging, CVRFs, and AD.

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An epidemiologic study of mild cognitive impairment in Kolkata, India

Cited by 142 publications

References 34 publications

Risk factors of dementia: a comparative study among the geriatric age group in Ernakulam, Southern India

Risk factors of dementia: a comparative study among the geriatric age group in Ernakulam, Southern India

Mild cognitive impairment: A comprehensive review

The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies

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