An epidemiological study of children with status epilepticus in Okayama, Japan: Incidence, etiologies, and outcomes

Nishiyama, Itsuko; Ohtsuka, Yoko; Tsuda, Toshihide; Kobayashi, Katsuhiro; Inoue, Hideo; Narahara, K; Saito, Hiroshi; Kimura, Takafumi; Ogawa, Makoto; Terasaki, Tomoyuki; Ono, Hiromichi; Takata, Tsutomu

doi:10.1016/j.eplepsyres.2011.05.004

Cited by 29 publications

(26 citation statements)

References 19 publications

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“…12,13 An epidemiological study of children with status epilepticus in Japan found that the incidence of SE among Japanese children was higher than the reported incidence among Caucasian children. 14 In our study, 26.0% cases experienced status epilepticus. Therefore, status epilepticus seems to be common in children with seizure in this region.…”

Section: Discussionsupporting

confidence: 48%

Clinical Profile, Aetiology and Outcome of Afebrile Seizures in Children

2013

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Introduction: Clinical and outcome profiles of childhood seizures can be different in resource limited settings where neurologists face lots of challenges in diagnosis and management of seizure. This study was conducted to investigate the clinical profile, causes and outcome of afebrile seizures in children in resource limited settings. Methods: This was a prospective hospital based study. Children with afebrile seizures were followed up with exclusion of febrile and acute provoked seizures. Clinical, investigation, treatment and outcome parameters were analyzed. Results: Study included 308 (age one month to 20 years) children. Median age at first seizure was 39 (inter quartile range 12-96) months. History of status epilepticus was present in 26.0%. Cause of seizure was known in 44.2%. Seizure was generalized in 79.2%, partial in 14.0% and unclassified in 6.8%. Common causes of seizure were – birth asphyxia (12.3%), neurocysticercosis (8.8%), sequel of nervous system infection (6.5%) and structural brain abnormalities (7.1%). Neurological examination, electroencephalography and computed tomography (CT) were abnormal in 24.4%, 70.5% and 27.9% cases respectively. Seizure control was achieved in 79.3% and by monotherapy in 85.0 % cases. Seizure control with single drug, seizure without recurrence and idiopathic seizure were associated with favourable outcome. Conclusions: Prevention and control of birth asphyxia, neurocysticercosis and nervous system infections are needed to reduce the burden of afebrile seizures in this area. CT is a valuable diagnostic tool and response to monotherapy is good. Seizure control with single drug, seizure without recurrence and idiopathic seizure are favourable prognostic factors. Keywords: afebrile seizure; children; clinical profile; outcome.

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Section: Discussionsupporting

confidence: 48%

Clinical Profile, Aetiology and Outcome of Afebrile Seizures in Children

2013

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“…Changes in the demographic profile in developed and developing countries have revealed the fastest growth to be in the older age group; therefore, SE is likely to become a common problem and an important health issue in years to come [13]. In the Asian continent, a not-so-different demographic profile is found, with a fairly equal sex distribution with 53%–57% males, a male-to-female ratio of 1.35:1 and an incidence of the first SE episode of 42/100,000/year [14,15,16]. Meanwhile, countries like Italy, France and Switzerland have an inverse male-to-female ratio [17,18,19,20].…”

Section: Resultsmentioning

confidence: 99%

“…For the Chinese adult population, the most common etiology was cerebrovascular disease (27%), followed by idiopathic (18%) and metabolic derangement (16%) and non-compliance with AEDs (14%) [14], while for 120 children <15 years of age between 2003 and 2005 in Japan, febrile SE accounted for 49.3% of cases, followed by acute symptomatic cases (17.5%) [16]. For the European population aged 20 or older, acute symptomatic SE ranges from 34%–60%, with a cerebrovascular pathology as the most common cause [17,18,20].…”

Section: Resultsmentioning

confidence: 99%

Status Epilepticus: Epidemiology and Public Health Needs

Sánchez

Rincón

2016

JCM

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Status epilepticus (SE) is defined as a continuous clinical and/or electrographic seizure activity lasting five minutes or more or recurrent seizure activity without return to baseline. There is a paucity of epidemiological studies of SE, as most research is derived from small population studies. The overall incidence of SE is 9.9 to 41 per 100,000/year, with peaks in children and the elderly and with febrile seizures and strokes as its main etiologies. The etiology is the major determinant of mortality. Governments and the academic community should predominantly focus on the primary prevention of etiologies linked to SE, as these are the most important risk factors for its development. This review describes the incidence, prevalence, etiology, risk factors, outcomes and costs of SE and aims to identify future research and public health needs.

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“…Influenza A causes 1 or more febrile seizure in 1 of 5 hospitalized children. 16 The other infections that were observed in the study alongside febrile seizure included the following: respiratory syncytial virus (4.8%), adenovirus (2.6%), and parainfluenza type 1 virus (0.5%). However, Chung et al 7 found that the incidence of febrile seizure (18.4%) in adenovirus-infected patients was similar to that in influenza virus and parainfluenza virus-infected patients, but significantly higher than respiratory syncytial virus (5.3%).…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Common Viral Upper Respiratory Tract Infections and Febrile Seizures in Children From Suzhou, China

Tang

Yan

et al. 2014

J Child Neurol

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This study aimed to determine the potential predisposing factors for the development of febrile seizures among children with upper respiratory tract infection in the eastern Chinese region. Participants were individuals aged 6 months and 6 years (n = 189) who were diagnosed with febrile seizure, complicated with upper respiratory tract infection, and 174 age-matched children who had upper respiratory tract infection without seizures as controls. The viral antigens including influenza A and B, parainfluenza, adenovirus, and respiratory syncytial virus were detected from nasopharyngeal aspirates. The incidence of influenza A infection was much higher in patients with febrile seizure than controls, especially those children aged >36 months. Patients with influenza A infection had higher body temperatures at seizure occurrence, shorter seizure duration, and shorter fever duration before seizure onset. Influenza A infections are frequently associated with febrile seizure in children with upper respiratory tract infection. During an influenza epidemic, effective vaccination of children, especially those with a past history of febrile seizure, may minimize the development of febrile seizure.

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An epidemiological study of children with status epilepticus in Okayama, Japan: Incidence, etiologies, and outcomes

Cited by 29 publications

References 19 publications

Clinical Profile, Aetiology and Outcome of Afebrile Seizures in Children

Clinical Profile, Aetiology and Outcome of Afebrile Seizures in Children

Status Epilepticus: Epidemiology and Public Health Needs

Relationship Between Common Viral Upper Respiratory Tract Infections and Febrile Seizures in Children From Suzhou, China

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