“…However, the variation in body size over an order of magnitude as shown in grey hounds, toys, companions, terriers, hunting and working dogs, may be more accurately described as a non-proportional function of body weight [26]. Since metabolic rate, body surface area (BSA), organ blood flow and glomerular filtration rate (GFR) depend on body weight [27], pharmacokinetic parameters and appropriate drug doses scale allometrically with body weight [36,37]. Allometric equation of the general form is: = b y aW , where y is the scalable variable, a is the mass coefficient, W represents body weight, and b is the mass exponent.…”