An epidemiological study of pulmonary arterial hypertension

Peacock, AJ; Murphy, Niamh; McMurray, John J.V.; Caballero, Luis; Stewart, Simon

doi:10.1183/09031936.00092306

Cited by 695 publications

(531 citation statements)

References 15 publications

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“…This value has been used for selecting patients in all RCTs and registries of PAH [3,4,8]. Recent re-evaluation of available data has shown that the normal P pa at rest is 14¡3 mmHg, with an upper limit of normal of ,20 mmHg [9,10].…”

Section: Definitionsmentioning

confidence: 99%

“…4. Referral centres are required to undertake a programme of clinical audit of outcomes, which will include survival analysis.…”

Section: Definition Of a Pulmonary Arterial Hypertension Referral Centrementioning

confidence: 99%

“…These have been classified into six clinical groups with specific characteristics (table 4) [1][2][3][4][5][6]. To highlight the remarkable differences between these clinical groups, a comparative description of pathology, pathobiology, genetics, epidemiology and risk factors is detailed in the first part.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Guidelines for the diagnosis and treatment of pulmonary hypertension

Galiè¹,

Hoeper²,

Humbert³

et al. 2012

Revista Portuguesa de Cardiologia (English Edition)

419

738

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Section: Definitionsmentioning

confidence: 99%

“…4. Referral centres are required to undertake a programme of clinical audit of outcomes, which will include survival analysis.…”

Section: Definition Of a Pulmonary Arterial Hypertension Referral Centrementioning

confidence: 99%

See 1 more Smart Citation

Guidelines for the diagnosis and treatment of pulmonary hypertension

Galiè¹,

Hoeper²,

Humbert³

et al. 2012

Revista Portuguesa de Cardiologia (English Edition)

419

738

View full text Add to dashboard Cite

“…Patients with pulmonary hypertension (PH) have a high mortality [1,2]. Symptoms can be subtle and there is frequently a long delay to diagnosis [1].…”

Section: Introductionmentioning

confidence: 99%

Regional contribution to ventricular stroke volume is affected on the left side, but not on the right in patients with pulmonary hypertension

Ostenfeld

Stephensen

Steding‐Ehrenborg

et al. 2016

Int J Cardiovasc Imaging

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59 ± 9 %, p < 0.0001 and p < 0.01, respectively). This decrease did not differ in patient with ejection fraction (eF) >50 % and <50 % (p = 0.5) and was compensated for by increased lV lateral contribution to lVSV in patients (49 ± 13 % vs. 37 ± 7 %, p = 0.001). Septal motion contributed less to lVSV in patients (5 ± 8 %) compared to controls (8 ± 4 %, p = 0.05). rV aVPD was lower in patients (12.0 ± 3.6 mm vs. 21.8 ± 2.2 mm, p < 0.0001) but longitudinal and lateral contribution to rVSV did not differ between patients (78 ± 17 % and 29 ± 16 %) and controls (79 ± 9 % and 31 ± 6 % p = 0.7 for both) explained by increased rV cross sectional area in patients. lV function is affected in patients with PH despite preserved global lV function. The decreased longitudinal contribution and increased lateral contribution to lVSV was not seen in the rV, contrary to previous findings in patients with volume loaded RVs. Abstract To develop more sensitive measures of impaired cardiac function in patients with pulmonary hypertension (PH), since detection of impaired right ventricular (rV) function is important in these patients. With the hypothesis that a change in septal function in patients with PH is associated with altered longitudinal and lateral function of both ventricles, as a compensatory mechanism, we quantified the contributions of these parameters to stroke volume (SV) in both ventricles using cardiac magnetic resonance (CMr). Seventeen patients (10 females) evaluated for PH underwent right heart catheterization (rHC) and CMr. CMr from 33 healthy adults (13 females) were used as controls. left ventricular (lV) atrioventricular plane displacement (aVPD) and corresponding longitudinal contribution to lVSV was lower in patients (10.8 ± 3.2 mm and 51 ± 12 %) compared to controls (16.6 ± 1.9 mm and 1 3 1244 int J Cardiovasc imaging (2016) 32:1243-1253 trols. The control group has been described in a previous study [11]. The regional ethical review board approved the study and written informed consent was obtained from all patients and healthy volunteers prior to CMr examination. Keywords Right heart catheterizationinvasive measurements were obtained during rHC with a triple-lumen Swan-ganz catheter in supine position and in local anesthesia. Pressures of pulmonary artery (PaP), right atrium, right ventricle and pulmonary artery wedge as well as cardiac output using thermodilution were measured. Precapillary PH was characterized by elevated mean pulmonary arterial pressure (mPaP) ≥25 mmHg and pulmonary artery wedge pressure ≤15 mmHg at normal or reduced cardiac output. Systemic pressure was available using a cuff and sphygmomanometer. Cardiac magnetic resonance imagingImage acquisition all subjects underwent CMr imaging in the supine position and images were acquired during end-expiratory breath-hold covering the entire heart, including both ventricles and atria. a 1.5 Tesla magnetic resonance imaging scanner was used for all studies (Philips achieva, Best, The netherlands). Steady state free precession cine images were ...

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“…5 A study from Scotland, however, cited the incidence as 2.5 cases/million/yr in men and 4.0 cases/million/yr in women. 6 Any age group can be affected, but most often iPAH occurs in the third decade of life in women and fourth decade of life in men. No ethnic predisposition has been reported.…”

Section: Epidemiologymentioning

confidence: 99%

Pulmonary hypertension—“state of the art” management in 2012

Saxena

2012

Indian Heart Journal

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A B S T R A C TPulmonary artery hypertension (PAH) is a pathological condition of small pulmonary arteries, characterised by vascular proliferation and remodelling. The pulmonary artery pressure and pulmonary vascular resistance progressively rise, leading to right heart failure and death. Pulmonary artery hypertension may be secondary to various conditions, or it may be idiopathic where no underlying cause is identifiable. Earlier, only symptomatic treatment was available for such patients which did not change the natural history of the disease. However, over the years, improvement in understanding the pathogenesis has resulted in the development of targeted approaches to the treatment of PAH. Survival advantage has also been shown with some of the pharmacologic agents. This review article discusses the current management strategy for PAH with special emphasis on an idiopathic variety, in an Indian context.

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An epidemiological study of pulmonary arterial hypertension

Cited by 695 publications

References 15 publications

Guidelines for the diagnosis and treatment of pulmonary hypertension

Guidelines for the diagnosis and treatment of pulmonary hypertension

Regional contribution to ventricular stroke volume is affected on the left side, but not on the right in patients with pulmonary hypertension

Pulmonary hypertension—“state of the art” management in 2012

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