An epidemiological study of the susceptibility and frequency of multiple-drug-resistant strains of Pseudomonas aeruginosa isolated at medical institutes nationwide in Japan

Susceptibility of Pseudomonas aeruginosa clinical isolates in Japan to doripenem and other antipseudomonal agents

“…Pseudomonas aeruginosa clinical isolates in Japan show a high rate of resistance to various antimicrobial agents, as reported by several authors [2,12,20,21]. No remarkable changes were observed from 1992 to 2004 with respect to the frequency of resistant strains to the tested agents, except for imipenem (Table 3).…”

Antimicrobial susceptibility and molecular epidemiological analysis of clinical strains of Pseudomonas aeruginosa

“…reports indicating an increasing trend of resistant P. aeruginosa strains, with a rate of resistance to IPM ranging from 19% to 36% depending on medical institutions. 3,4,7,9,10,14,15 In 2003, Yoshida et al 15 reported surveillance data of the susceptibility of Gram-negative clinical isolates to various antimicrobial agents. Against non-carbapenem β-lactams, aminoglycosides, and fl uoroquinolones, the resistance rates of our isolates were lower by 1.2%-3.3% than those reported by Yoshida et al, whereas the resistance rate of our isolates to carbapenems was higher by 14.9%-19.3%, demonstrating an increasing trend of P. aeruginosa strains resistant to carbapenems in our hospital.…”

“…The frequencies of isolation of MDRP and metallo-β-lactamase producing strains in our hospital were 1.6% and 0.81%, respectively, which are comparable to those observed in other institutions. [2][3][4][5][6][7]9,17 Pseudomonas aeruginosa easily causes nosocomial infections, especially in immunocompromised hosts. Several nosocomial outbreaks of MDRP and metallo-β-lactamase producers have been reported.…”

“…To take effective measures against nosocomial infection, it is critically important to obtain accurate information about the drug susceptibility of these resistant P. aeruginosa strains and their epidemiology. 3,4,[7][8][9][10] We investigated the drug susceptibility or resistance of P. aeruginosa from clinical isolates collected in our hospital from May 2002 through January 2003, and isolation rates of metallo-β-lactamase producing strains and MDRP strains. At the same time, we performed molecular epidemiological analysis of MDRP, metallo-β-lactamase producing strains, and imipenem (IPM)-resistant strains.…”

Relation between the Antimicrobial Susceptibility of Clinical Isolates of Pseudomonas aeruginosa from Respiratory Specimens and Antimicrobial Use Density (AUD) from 2005 through 2008

“…Recently, multidrug-resistant P. aeruginosa strains have emerged and are now frequently isolated clinically; nosocomial infections due to resistant strains have become an important problem (3)(4)(5). The high use of broad-spectrum antimicrobials such as carbapenems has contributed to the emergence of resistant strains of P. aeruginosa (6,7).…”