An epidemiology study of patients with uremic pruritus

Mistik, Selcuk; Utaş, Serap; Ferahbaş, Ayten; Tokgöz, Bülent; Ünsal, Gülbin; Şahan, Haluk Furkan; Öztürk, Agah Bahadır; Utaş, Cengiz

doi:10.1111/j.1468-3083.2006.01570.x

Cited by 89 publications

(91 citation statements)

References 18 publications

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“…Mistik et al reported that 50.2% of the patients that received hemodialysis treatment had pruritus at the time of the study period (10). Various related studies have stated that 22-90% of the patients suffered from pruritus (2,9-16).…”

Section: Discussionmentioning

confidence: 99%

An Important Problem Among Hemodialysis Patients: Uremic Pruritus

Akça¹,

Taşçı²

2014

Turk Neph Dial Transpl

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ObJECTIVE: This study was conducted in order to determine the incidence of uremic pruritus in hemodialysis patients and to explore the associated factors. MATErIAL and METHODS:This descriptive study included 204 patients. Official permissions from the institutions and informed consents of the patients were obtained. The data were gathered using a questionnaire form designed by the investigators and the Visual Analogue Scale (VAS). The t test, one-way ANOVA and logistic regression analysis were used for the statistical analyses of the data. rESULTS:We found that 75.5% of the patients suffered from pruritus after hemodialysis treatment was initiated and 64.2% of them had an average level of pruritus (6.0±2.0) at the time of the study. It was noted that 37.4% had wounds caused by pruritus and 61.1% woke up from their sleep due to pruritus. Patients who were aged ≥ 65 were 3.91 times more likely to suffer from very severe pruritus compared to other age groups and patients with dry skin were 9.90 times more likely to suffer from very severe pruritus as compared to those with normal skin (p<0.05) CONCLUSION:In light of these results, it may be recommended that patients who suffer from uremic pruritus should be provided with the necessary care and training programs, taking into account their individual and disease-related characteristics. KEy wOrDS: Uremic pruritus, Hemodialysis, Affecting factorsÖz AMAÇ: Bu çalışma, hemodiyaliz tedavisi alan bireylerin yaşadığı üremik kaşıntı ve kaşıntıyla ilişkili faktörleri belirlemek amacıyla yapılmıştır. GErEÇ ve yÖNTEMLEr:Tanımlayıcı nitelikte yapılan bu çalışma, araştırmaya katılmayı kabul eden 204 kişi üzerinde yapılmıştır. Çalışmada, kurum izni ve bireylerden yazılı onam alınmıştır. Veriler araştırmacılar tarafından oluşturulan anket formu ve Visual Analog Skala (VAS) aracılığı ile toplanmıştır. Verilerin istatistiki değerlendirilmesinde, Student t, ANOVA testi ve lojistik regresyon analizi kullanılmış ve p<0.05 anlamlı olarak kabul edilmiştir.bULGULAr: Bireylerin %75,5'inin hemodiyaliz tedavisine başladıktan sonra kaşıntısının olduğu, %64,2'sinin ise çalışmanın yapıldığı anda ortalama 6,0±2,0 (2-10) düzeyde (şiddetli) kaşıntı yaşadıkları saptanmıştır. Bireylerin %37,4'inin kaşıntı sonucu vücudunda yaralar olduğu ve %61,1'inin kaşıntı nedeniyle uykusundan uyandığı belirlenmiştir. Diğer yaş gruplarıyla karşılaştırıldığında 65 yaş üstü hastaların 3,91 kat ve derisi kuru olan hastaların ise derisi normal olanlara göre 9,90 kat daha şiddetli kaşıntı yaşadığı tespit edilmiştir (p<0,05). SONUÇ:Bu sonuçlar doğrultusunda, üremik kaşıntı yaşayan bireylerin bireysel ve hastalık özellikleri dikkate alınarak eğitim ve bakım yapılması önerilebilir.

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Section: Discussionmentioning

confidence: 99%

An Important Problem Among Hemodialysis Patients: Uremic Pruritus

Akça¹,

Taşçı²

2014

Turk Neph Dial Transpl

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“…Uremic itch is believed to be the result of a complex contribution of numerous uremic and non-uremic factors. Known risk factors predisposing to uremic pruritus include male gender, 18 elevated serum levels of calcium, phosphorus, magnesium, urea, and β 2 -microglobulin. 19,20 Other contributing factors comprise xerosis, anemia, high serum aluminum level, increased calcium × phosphate product, hypervitaminosis A, erythropoietin insufficiency, low albumin, low transferrin, elevated ferritin, secondary hyperparathyroidism, dialysis membrane material, inefficient dialysis, systemic inflammation, uremic neuropathy, allergic sensitization, elevated serum histamine level, intradermal mast cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Panahi¹,

Dashti‐Khavidaki²,

Farnood³

et al. 2016

Adv Pharm Bull

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“…There is conflicting evidence regarding the relationship between the onset and severity of pruritus and the duration of ESRD and dialysis therapy (11,12,16). No clear association between pruritus and underlying renal disease has been established (12). The proportion of ESRD patients with uremic pruritus has decreased significantly with modern dialysis from approximately 85% in the 1970s to the present day rate of 40%-50% (11,17,18).…”

Section: Nonspecific Manifestationsmentioning

confidence: 99%

“…The exact pathophysiology of uremic pruritus is unknown, but it is likely multifactorial. Possible etiological factors are presented in Table 2 (11)(12)(13)(14)(15). There is conflicting evidence regarding the relationship between the onset and severity of pruritus and the duration of ESRD and dialysis therapy (11,12,16).…”

Section: Nonspecific Manifestationsmentioning

confidence: 99%

Cutaneous Manifestations of ESRD

Galperin

Cronin

Leslie

2014

Clinical Journal of the American Society of Nephrology

193

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SummaryA broad range of skin diseases occurs in patients with ESRD: from the benign and asymptomatic to the physically disabling and life-threatening. Many of them negatively impact on quality of life. Their early recognition and treatment are essential in reducing morbidity and mortality. The cutaneous manifestations can be divided into two main categories: nonspecific and specific. The nonspecific manifestations are commonly seen and include skin color changes, xerosis, half-and-half nails, and pruritus. The specific disorders include acquired perforating dermatosis, bullous dermatoses, metastatic calcification, and nephrogenic systemic fibrosis. This review article describes these conditions and considers the underlying pathophysiology, clinical presentations, diagnosis, and treatment options.

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An epidemiology study of patients with uremic pruritus

Abstract: This study showed us that uremic pruritus was observed more in men than women. The high prevalence of uremic pruritus in our study does not support the decrease of pruritus due to an improvement in the management of dialysis patients.

Cited by 89 publications

References 18 publications

An Important Problem Among Hemodialysis Patients: Uremic Pruritus

An Important Problem Among Hemodialysis Patients: Uremic Pruritus

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Cutaneous Manifestations of ESRD

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