An europium functionalized carbon dot-based fluorescence test paper for visual and quantitative point-of-care testing of anthrax biomarker

Wang, Jing; Li, Daquan; Qiu, Yuping; Liu, Xinyue; Huang, Liang; Wen, Haiming; Hu, Jun

doi:10.1016/j.talanta.2020.121377

Cited by 56 publications

(25 citation statements)

References 49 publications

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“…The fluorescent lateral flow assay owned good reproducibility, high specificity and sensitivity due to the excellent fluorescent properties of CSNs, and was able to achieve a low visual detection limit of as low as 10 pg mL −1 SFTSV nucleoprotein which was 2 orders of magnitude higher than that of the colloidal gold-based lateral flow test strip. Most recently, Wang et al [151] developed a Eu(III) functionalized carbon dots (CDs-Eu)-based ratiometric fluorescent test paper for sensitive POC detection of dipicolinic acid (DPA), a biomarker of anthrax. This ratiometric fluorescent test paper exhibited excellent detection performance with high sensitivity which could achieve a linearity range from 0.5 nM to 5 μM and a detection limit of 0.8 nM.…”

Section: Detection Methods For Poc Diagnostic Applicationsmentioning

confidence: 99%

Point-of-care diagnostics for infectious diseases: From methods to devices

et al. 2021

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Section: Detection Methods For Poc Diagnostic Applicationsmentioning

confidence: 99%

Point-of-care diagnostics for infectious diseases: From methods to devices

et al. 2021

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“…The most important thing is that the output signal of POCT is very simple and easy to get, usually including color, distance, pressure, temperature, etc. [131][132][133][134][135].…”

Section: Detection Methods Based On Point-of-care Testing (Poct)mentioning

confidence: 99%

“…Recently, Wang et al also used a smart phone, to determine anthrax based on color change, using Eu(III) functionalized carbon dots (CDs-Eu) as a fluorescent probe, where DPA (an anthrax biomarker) can interact with CDs-Eu, resulting in a color change. Using the color analysis software on the smartphone, DPA can be quantified, and its linear range is 0.5 nM to 5 µM with a LOD of 0.8 nM ( Figure 6D) [131]. Xiao et al designed an optical microfiber sensor modified by a polystyrene@gold nanosphere to detect the (CEA)-related cell adhesion molecules 5 (CEACAM5) concentration in serum.…”

Section: Poct Based Detection Of Enzyme Activity/proteins/compoundmentioning

confidence: 99%

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Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Han

Sun

et al. 2020

Sensors

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Circulating tumor cells (CTCs) are tumor cells that escaped from the primary tumor or the metastasis into the blood and they play a major role in the initiation of metastasis and tumor recurrence. Thus, it is widely accepted that CTC is the main target of liquid biopsy. In the past few decades, the separation of CTC based on the electrochemical method has attracted widespread attention due to its convenience, rapidness, low cost, high sensitivity, and no need for complex instruments and equipment. At present, CTC detection is not widely used in the clinic due to various reasons. Point-of-care CTC detection provides us with a possibility, which is sensitive, fast, cheap, and easy to operate. More importantly, the testing instrument is small and portable, and the testing does not require specialized laboratories and specialized clinical examiners. In this review, we summarized the latest developments in the electrochemical-based CTC detection and point-of-care CTC detection, and discussed the challenges and possible trends.

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“…Anthracnosis is a zoonotic, severe infectious disease caused by Bacillus anthrax, in which spores may be transmitted by food, water and air. [1][2][3][4][5][6][7] The inhalation of 10 4 Bacillus anthracis spores is deadly without treatment within 24-48 hours. [8][9][10] Anthrax has a microstructure that is highly resistant to extreme environments and can resist environments such as high temperature and high pressure, drought, ultraviolet irradiation, chemical disinfectants, strong acids and alkalis.…”

Section: Introductionmentioning

confidence: 99%