The purpose of this research was to know the general hospital locations which are in the zone the earthquake hazard potentially tsunami to optimize the response of disaster victims and formulate a general hospital preparedness policy model in dealing with victims of the earthquake hazard potentially tsunami. The research focusing on accessibility aspects was analyzed using GIS Arc-GIS 10.5 analysis technique, while the general hospital preparedness policy model in the response to victims of the earthquake hazard potentially tsunami in Mentawai Islands Regency was using the Analytic Hierarchy Process (AHP) technique. The reseach results show that the development of settlements in regions not designated for settlements, especially in the hazard zone high has the highest weight value (0,750). Then followed by composing zones of hazard level to develop an early warning system (0,600), empowering people who carry out activities in the hazard zone high (0,525), compile of land allotment zones for settlements (0,500), and conduct coaching, training, and technical guidance to the people, government apparatus, private sector and hospital staff in stages and continuously (0,488).