An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Nevill, B G; Leisewitz, Andrew L.; Goddard, Amelia; Thompson, Peter

doi:10.4102/jsava.v81i1.90

Cited by 17 publications

(23 citation statements)

References 31 publications

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“…31 In another study, serum CK activity was measured over 48 hours after HL and OVH. 32 Similar to our study, clear stratification in serum CK activity was observed according to the type of surgery. In that study, serum CK activity after HL did not return to baseline at 48 hours.…”

Section: Discussionsupporting

confidence: 89%

“…This assumption is based on a single pharmacokinetic study in which the supernatants of dog muscle homogenates were injected IV and IM into 6 dogs . In another study, serum CK activity was measured over 48 hours after HL and OVH . Similar to our study, clear stratification in serum CK activity was observed according to the type of surgery.…”

Section: Discussionsupporting

confidence: 74%

“…In that study, serum CK activity after HL did not return to baseline at 48 hours. We followed plasma CK activity longer than in the previous study 32 and found that, in the HL group, plasma CK activity did not return to baseline even after 72 hours. Both our study and the previous study 32 indicate that plasma CK activity is proportional to the extent of muscle injury and that the biological half-life is approximately 28 hours.…”

Section: Discussionmentioning

confidence: 81%

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Kinetics of Plasma Cell‐Free DNA and Creatine Kinase in a Canine Model of Tissue Injury

Wilson

Burchell

Worth

et al. 2017

Veterinary Internal Medicne

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BackgroundCell‐free DNA (cfDNA) comprises short, double‐stranded circulating DNA sequences released from damaged cells. In people, cfDNA concentrations correlate well with disease severity and tissue damage. No reports are available regarding cfDNA kinetics in dogs.Objectives/HypothesisCell‐free DNA will have a short biological half‐life and would be able to stratify mild, moderate, and severe tissue injury. Our study aims were to determine the kinetics and biological half‐life of cfDNA and to contrast them with those of creatine kinase (CK).AnimalsThree groups of 10 dogs undergoing open ovariohysterectomy, surgery for cranial cruciate ligament rupture (CCLR), or hemilaminectomy.MethodsPlasma for cfDNA and CK analysis was collected at admission, at induction of anesthesia, postsurgery (time 0) and at 6, 12, 24, 36, 48, 60, and 72 hours after surgery.ResultsThe biological half‐life of plasma cfDNA and CK were 5.64 hours (95% confidence interval [CI 95], 4.36–7.98 hours) and 28.7 hours (CI95, 25.3–33.3 hours), respectively. In the hemilaminectomy group, cfDNA concentrations differed significantly from admission at 6–12 hours after surgery. Creatine kinase activity differed among the surgical groups and reached a peak 6 hours after surgery. In the ovariohysterectomy and CCLR groups, plasma CK activity 72 hours after surgery did not differ from admission activity of the ovariohysterectomy group. In contrast, in the hemilaminectomy group, plasma CK activity after 72 hours did not return to the ovariohysterectomy group admission activity.Conclusions and Clinical ImportancePlasma CK activity has a longer biological half‐life than previously thought. In contrast to plasma CK activity, cfDNA has a short half‐life and could be a useful marker for peracute severe tissue injury.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 81%

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Kinetics of Plasma Cell‐Free DNA and Creatine Kinase in a Canine Model of Tissue Injury

Wilson

Burchell

Worth

et al. 2017

Veterinary Internal Medicne

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“…CK and AST have been measured in serum of dogs as a marker of muscle damage under different conditions, such as hemilaminectomy or ovariohysterectomy [16], exercise [10], and after anesthesia [17]. However, to the authors’ knowledge no studies about CK and AST in saliva in dogs have been published previously.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Creatine kinase and Aspartate aminotransferase in saliva of dogs: a pilot study

et al. 2017

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BackgroundMuscle enzymes in saliva have been reported to be possible markers of heart and muscle damage in humans. The aim of this study was to assess if Creatine kinase (CK) and Aspartate aminotransferase (AST) activities could be measured in canine saliva, and to evaluate their possible changes in situations of muscle damage.ResultsThe spectrophotometric assays for CK and AST measurement in saliva of dogs showed intra- and inter-assay imprecision lower than 1 and 16% and coefficients of correlation close to 1 in linearity under dilution tests. Healthy dogs showed activities in saliva of CK between 27 and 121 U/L and AST between 46 and 144 U/L, whereas in saliva of dogs with muscle damage CK ranged between 132 and 3862 U/L and AST between 154 and 4340 U/L. Positive moderate correlations were found between saliva and serum activities of the two enzymes (CK, r = 0.579; P = 0.001; AST, r = 0.674; P = 0.001).ConclusionsCK and AST activities can be measured in canine saliva with commercially available spectrophotometric assays. In addition these enzymes show higher values in saliva of dogs with muscle damage and their values are moderately correlated with those of serum.

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“…37 Increases in plasma CK activity in dogs are associated with cell-membrane leakage and therefore will be evident in any condition associated with muscular inflammation, necrosis, or degeneration. 38,39 Creatine kinase has a half-life of only 2 to 3 hours. 40 Thus, high serum CK activity is indicative of recent and active muscle injury.…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise on serum markers of muscle inflammation in Spanish Greyhounds

Lucas¹,

Barrera²,

Duque³

et al. 2015

ajvr

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An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Cited by 17 publications

References 31 publications

Kinetics of Plasma Cell‐Free DNA and Creatine Kinase in a Canine Model of Tissue Injury

Kinetics of Plasma Cell‐Free DNA and Creatine Kinase in a Canine Model of Tissue Injury

Measurement of Creatine kinase and Aspartate aminotransferase in saliva of dogs: a pilot study

Effect of exercise on serum markers of muscle inflammation in Spanish Greyhounds

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