An evaluation of clinical accuracy of the EasyTouch blood uric acid self-monitoring system

Dai, Ken-Shwo; Tai, Der-Yan; Ho, P. Michael; Chen, Chien-Chih; Peng, Wen-Chung; Chen, Shih-Te; Hsu, Chun-Chieh; Liu, Yuping; Hsieh, Hsiu-Ching; Mao, Simon J.T.

doi:10.1016/j.clinbiochem.2004.11.005

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Serum PSA (KLK3) was measured by ELISA (R&D Systems) according to the manufacturer's instructions. Uric acid was measured as previously described (37).…”

Section: Methodsmentioning

confidence: 99%

Antitumor activity of a pyrrole-imidazole polyamide

Yang

Nickols

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

113

132

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Many cancer therapeutics target DNA and exert cytotoxicity through the induction of DNA damage and inhibition of transcription. We report that a DNA minor groove binding hairpin pyrroleimidazole (Py-Im) polyamide interferes with RNA polymerase II (RNAP2) activity in cell culture. Polyamide treatment activates p53 signaling in LNCaP prostate cancer cells without detectable DNA damage. Genome-wide mapping of RNAP2 binding shows reduction of occupancy, preferentially at transcription start sites, but occupancy at enhancer sites is unchanged. Polyamide treatment results in a time-and dose-dependent depletion of the RNAP2 large subunit RPB1 that is preventable with proteasome inhibition. This polyamide demonstrates antitumor activity in a prostate tumor xenograft model with limited host toxicity.minor groove binder | small molecule transcription inhibitor | ChIP-Seq

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“…Serum PSA (KLK3) was measured by ELISA (R&D Systems) according to the manufacturer's instructions. Uric acid was measured as previously described (37).…”

Section: Methodsmentioning

confidence: 99%

Antitumor activity of a pyrrole-imidazole polyamide

Yang

Nickols

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

113

132

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“…All these methods indicate that both methods are similar and can be used instead of each other depending on the more available, cheap and faster method. Dai et al (2005) found that EasyTouch ® is an acceptable diagnostic device which accurate uric acid measurements. Also, EasyTouch ® provided high accurate and precise glucose readings over a wide range of glucose concentrations (Dai et al, 2004).…”

Section: (2004); Argyropoulou Et Al (2007); Chatterjee and Bajoria mentioning

confidence: 95%

COMPARATIVE STUDY BETWEEN MEASUREMENTS OF SERUM CHOLESTEROL, URIC ACID AND GLUCOSE IN CHILDREN WITH Β-Thalassemia BY LABORATORY AND BEDSIDE METHODS.

Abdelmotaleb¹,

Abdo²,

Abdelmonaem³

et al. 2017

IJAR

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Background: In Egypt, β-thalassemia is the commonest cause of chronic hemolytic anemia, it considered as major public health problem. Methods: This study was a case control study included thirty thalassemia major children (from 4-18 years) and thirty age and sex matched healthy children with total mean age (7.15). All children were subjected to full medical history taking and full clinical examination. Random blood samples were collected from patient and control groups (5 ml fresh blood) for hematological parameters (CBC, Reticulocyte count). Cholesterol, uric acid and glucose levels were measured twice {laboratory by spectrophotometric method and bedside test using strips of multi-function meter EasyTouch ® GCU}. Results: The main complaint of thalassemic children was pallor followed by (diarrhea, vomiting, abdominal enlargement or cough) followed by jaundice. Age at diagnosis was found to range from 9-48 months. Frequency of blood transfusion was found to be twice per month (56.7%). Patients were treated with one of three types of iron chelating agents (FPX ® , Desferal ® and Exjade ®). Hemoglobin (Hb) concentration, Mean corpuscular volume (MCV) were decreased significantly (p<0.05). Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelet (PLT) counts were found to decrease insignificantly in patient group than control group, while reticulocyte count increased significantly in patient group than control. A positive significant correlation (p<0.05) was found between serum ferritin and frequency of blood transfusion and there were no significant differences in serum ferritin levels according to chelating agents used in patient group. Cholesterol level was decreased significantly (P<0.001) in -thalassemia patients than healthy children. Serum uric acid and glucose concentrations were increased significantly in thalassemic patient group than the control group. Conclusion: EasyTouch ® GCU multi-function monitoring system promise quick and accurate concentrations of cholesterol, uric acid and glucose compared to traditional laboratory measurements.

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“…Conventional uric acid detection in blood or urine requires bulky equipment and sufficient samples. The portable testing kit detects uric acid in blood uses disposable test strips and requires a drop of blood obtained by finger prick with a lancet [76], [77]. The method is valuable for monitoring blood in screening gout, cardiovascular diseases, and diabetes [78], [79], however may be appropriate to monitor wound fluid in situ.…”

Section: G Bandage Configurationmentioning

confidence: 99%

Porous Polypropylene Membrane Based pH Sensing for Skin Monitoring

et al. 2022

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An iridium oxide-based electrical pH sensor that is suitable to be embedded in an electronic bandage for skin monitoring has been developed. The electrical pH sensor does not entail high-temperature fabrication processes thus is suitable to be built on polypropylene micro membrane (PPMM), a paperlike substrate, which is inert, gas-permeable, and biomechanically-compatible to tissue. The PPMM was metalized by an electroless gold-coating process and iridium oxide nanoparticles were electrodeposited on the porous membranes. The reference electrode was made by screen printing Ag/AgCl paste on the substrate. pH responses of the IrO 2 PPMM against a commercial reference electrode or the planar Ag/AgCl reference electrode were examined. A super-Nernstian sensitivity of −66.8 mV/pH was achieved with the PPMMbased sensor in a pH range from pH 2 to 13. The electrodes also produced similar responses in smaller pH ranges of pH 5 to 8 and around pH 7. Output potential characterization, such as cyclic voltammetry, hysteresis, response time, potential drift, deviation, fluctuation, and potential stability, showed repeatable and stable pH responses in physiologically relevant pH ranges. Interference factors such as salt concentration, viscosity and temperature have also been investigated. The results show that the calibration procedures should consider these factors specific to targeted applications. The planar pH-sensitive electrodes show reliable performance in a bandage configuration designed and packaged for wound monitoring. The accuracy assessment in a Clarke error grid and the result of sensing pH induced by uric acid showed the feasibility of bandage applications. The electrical and biocompatible electrodes embedded in breathable porous bandages can be integrated with portable electronics to be used as wearables for wireless tissue monitoring.INDEX TERMS pH sensor, planar, iridium oxide, polypropylene micro membrane, electronic bandage.

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An evaluation of clinical accuracy of the EasyTouch blood uric acid self-monitoring system

Cited by 7 publications

References 17 publications

Antitumor activity of a pyrrole-imidazole polyamide

Antitumor activity of a pyrrole-imidazole polyamide

COMPARATIVE STUDY BETWEEN MEASUREMENTS OF SERUM CHOLESTEROL, URIC ACID AND GLUCOSE IN CHILDREN WITH Β-Thalassemia BY LABORATORY AND BEDSIDE METHODS.

Porous Polypropylene Membrane Based pH Sensing for Skin Monitoring

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