An evaluation of different doses of soluble aspirin and aspirin tablets in postoperative dental pain.

Holland, I. S.; Seymour, R. A.; Ward-Booth, R.P.; Ord, Robert A.; Lim, Kiwon; Hoare, Robert

doi:10.1111/j.1365-2125.1988.tb03406.x

Cited by 18 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This has led to the impression that aspirin is relatively weak and slow acting. Previous studies 3,4 have shown that soluble aspirin provides a greater onset of action and is overall more effective than solid aspirin. However, up to the present time, there has been no study comparing the efficacy of soluble aspirin with solid paracetamol.…”

Section: Introductionmentioning

confidence: 99%

An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery

et al. 2003

View full text Add to dashboard Cite

Objective To compare the efficacy of soluble aspirin 900 mg and paracetamol 1,000 mg in patients with postoperative pain after third molar surgery. Design A randomised, placebo controlled, double-blind study. Setting Day stay units of Oral and Maxillofacial Surgery at Cardiff Dental Hospital and Hexham General Hospital, Northumberland. Subjects and methods One hundred and sixty-seven (104 female) patients who required the removal of their impacted third molars under general anaesthesia. Intervention In the early postoperative period, patients were medicated with either a single dose of soluble aspirin 900 mg, solid paracetamol 1,000 mg or placebo. Main outcome measures Pain intensity was measured on 100 mm visual analogue scales at 0,5,10, 15, 20, 30, 45, 60, 90, 120 and 240 minutes after dosing. Other efficacy variables evaluated included time to rescue medication and an overall assessment of the study medication efficacy by the patient on completion of the study. Results One hundred and sixty-seven patients consented to take part in the study, but only 153 were medicated. Of the 14 patients not treated, 10 failed to develop sufficient pain to enter the study, two withdrew consent, one had an adverse reaction to the general anaesthetic and one was a protocol violator. Over the four hour investigation period, patients treated with soluble aspirin reported significantly less pain when compared with those treated with paracetamol (mean difference in AUC 0-240 = -2001, 95% CI -3893 to -109, p=0.038) and placebo (mean difference in AUC 0-240 = -3470, 95% CI -5719 to -1221, p=0.003).

show abstract

Section: Introductionmentioning

confidence: 99%

An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery

et al. 2003

View full text Add to dashboard Cite

show abstract

“…In these efficacy studies ibuprofen has been given as a tablet. In a previous study, we showed that the formulation of aspirin was an important determinant of efficacy in the treatment of postoperative dental pain (Holland et al, 1988). Soluble aspirin provided an earlier and more prolonged period of pain control than aspirin tablets when used in the immediate period after third molar surgery.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of different ibuprofen preparations in the control of postoperative pain after third molar surgery.

Seymour

Hawkesford

Weldon

et al. 1991

Brit J Clinical Pharma

Self Cite

View full text Add to dashboard Cite

1. Two separate placebo‐controlled studies of parallel design were carried out to evaluate the efficacy of single doses (400 mg) of soluble ibuprofen, ibuprofen liquid in a gelatin capsule and ibuprofen tablets (Nurofen), in patients with postoperative pain after third molar surgery. 2. All ibuprofen preparations provided significant pain relief (P less than 0.05) over a 6 h investigation period. 3. Mean pain scores after ibuprofen tablets and ibuprofen liquid in a gelatin capsule were similar. 4. Soluble ibuprofen 400 mg provided an earlier onset of pain relief (20 min) than ibuprofen tablets (30 min). 5. No unwanted effects were reported in the various ibuprofen treatment groups. 6. The ibuprofen preparations evaluated in this study are effective up to 4 h for controlling postoperative pain after third molar surgery. The soluble form is more efficacious with regard to onset of action.

show abstract

“…In previous singledose studies, we have shown that soluble aspirin provided an earlier onset and more prolonged analgesia than the corresponding dose of aspirin tablets in patients with postoperative pain after third molar surgery (Holland et al, 1988;Seymour et al, 1986). Differences in efficacy were attributed to the earlier and greater peak concentrations of ASA after soluble aspirin than after tablets (Levy, 1965;Rance et al, 1975).…”

Section: Discussionmentioning

confidence: 97%

“…Using a similar methodology, we have previously shown aspirin tablets 600-900 mg afforded little pain relief when compared with the same doses of soluble aspirin (Holland et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…In a series of single dose studies, we have shown that aspirin-induced analgesia in postoperative dental pain is related to dose and formulation (Seymour & Rawlins, 1982;Seymour et al, 1986). On a dose per dose basis, soluble aspirin provided an earlier onset of analgesia than aspirin tablets in the immediate postoperative period after third molar surgery (Holland et al, 1988). We also demonstrated that plasma concentrations of acetylsalicylate correlated with plasma aspirin esterase activity, and both factors were significant determinants of the drug's efficacy (Seymour et al, 1984a).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An evaluation of buffered aspirin and aspirin tablets in postoperative pain after third molar surgery.

Seymour¹,

Weldon²,

Kelly³

et al. 1992

Brit J Clinical Pharma

Self Cite

View full text Add to dashboard Cite

1. Single doses (500 and 1000 mg) of both buffered aspirin and aspirin tablets were compared with placebo in a randomised double‐blind trial of parallel design in patients with postoperative pain after third molar surgery. 2. Only buffered aspirin 500 mg provided significant pain relief (P = 0.016) during the 5 h investigation period. 3. A significant correlation (P = 0.004) was observed between overall pain scores after the various aspirin treatments and aspirin esterase activity. 4. Buffered aspirin preparations afforded a slight advantage over aspirin tablets in the control of postoperative pain after third molar surgery. However, the duration of analgesia was short (approximately 2 h). 5. Aspirin esterase activity appears to be an important determinant of the drug's efficacy in postoperative dental pain.

show abstract

An evaluation of different doses of soluble aspirin and aspirin tablets in postoperative dental pain.

Cited by 18 publications

References 14 publications

An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery

An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery

An evaluation of different ibuprofen preparations in the control of postoperative pain after third molar surgery.

An evaluation of buffered aspirin and aspirin tablets in postoperative pain after third molar surgery.

Contact Info

Product

Resources

About