The artificial immune system, an excellent prototype for developing Machine Learning, is inspired by the function of the powerful natural immune system. As one of the prevalent classifiers, the Dendritic Cell Algorithm (DCA) has been widely used to solve binary problems in the real world. The classification of DCA depends on a data preprocessing procedure to generate input signals, where feature selection and signal categorization are the main work. However, the results of these studies also show that the signal generation of DCA is relatively weak, and all of them utilized a filter strategy to remove unimportant attributes. Ignoring filtered features and applying expertise may not produce an optimal classification result. To overcome these limitations, this study models feature selection and signal categorization into feature grouping problems. This study hybridizes Grouping Genetic Algorithm (GGA) with DCA to propose a novel DCA version, GGA-DCA, for accomplishing feature selection and signal categorization in a search process. The GGA-DCA aims to search for the optimal feature grouping scheme without expertise automatically. In this study, the data coding and operators of GGA are redefined for grouping tasks. The experimental results show that the proposed algorithm has significant advantages over the compared DCA expansion algorithms in terms of signal generation.