An evaluation of six-year Stenotrophomonas maltophilia infections in a university hospital

Abstract

Background: Stenotrophomonas maltophilia is a Gram-negative bacillus and opportunistic emergent pathogen causing hospi- tal-acquired infections (HAIs). Due to risk factors such as prolonged intensive care unit stay and invasive procedures, it has become one of the leading causes of HAIs.
 Objective: The aim of this study was to evaluate the epidemiology of S.maltophilia infections over a six-year period at Düzce University Hospital, Turkey.
 Methods: The incidence, clinical characteristics, antimicrobial susceptibility and outcomes of nosocomial S. maltophilia in- fections during this period were retrospectively analyzed.
 Results: During the study period, 67 samples obtained from 61 patients were identified. Pneumonias (82%) were the most common HAIs, followed by bloodstream infections (10.5%), urinary tract infections (3%), skin and soft tissue infections (3%) and surgical site infection (1.5%). Admission to intensive care, hospitalization exceeding 30 days, and previous use of broad-spectrum antibiotics constituted risk factors. Resistance to cotrimoxazole (6%) was lower than that to levofloxacin (18%).
 Conclusion: The most important risk factors for S.maltophilia infection in patients are previous exposure to antibiotics, pro- longed hospitalization and invasive procedures such as mechanic ventilation. Discharging patients as early as possible with the rational use of antibiotics may be effective in reducing S. maltophilia infections and resistance rates.
 Keywords: Stenotrophomonas maltophilia; hospital-acquired infections; epidemiology; risk factors.

Antimicrobial Resistance in Clinical Strains of Stenotrophomonas maltophilia: 10-year surveillance

“…İnce N ve ark. 'nın (14) 61 hastayı değerlendirdikleri çalışmada yoğun bakımda yatış oranı %82, mortalite %49 (30/61), ortalama hastanede yatış süresi 75.01 gün olarak bildirilmektedir. Çalışmamızda ise 2014 Ocak-2019 Aralık yılları arasında mortalite oranı %21.1, ortalama hastanede yatış süresi 19.5 gün olarak saptanmıştır.…”

Emerging infections in vulnerable hosts: Stenotrophomonas maltophilia and Elizabethkingia anophelis

“…The rates of susceptibility of S. maltophilia to antimicrobial agents reported during 2020–2022 are listed in Table 2[28–30,39,49,95–120]. TMP-SMZ is the current treatment of choice for S. maltophilia infections because of its good in vitro susceptibility rates and extensive use in clinical settings.…”

Twenty years of African Health Sciences as infections continue to plague our continent

“…We have a bench guide on the review of phenotypic assays for detection of extended-spectrum β-lactamases and carbapenemases 10 ; and a report on vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of symptomatic individuals 11 . Its followed by an evaluation of Stenotrophomonas maltophilia infections in a university hospital 12 ; bacterial meningitis in Tunisian children 13 , and “unnecessary antimicrobial prescriptions for upper respiratory tract infections in children in South Africa 14 . Other infections: From Pakistan 15 we have a report on the detection, quantification and genotype distribution of hepatitis C virus(HCV) patients by real-time PCR); while from Saudi Arabia we have a paper on haemorrhagic fever as a challenge to public health, effective management and future considerations.…”