An Evidence Based Approach of Use of Topical Corticosteroids in Dermatology

Das, Anupam; Panda, Saumya

doi:10.1007/978-981-10-4609-4_4

Cited by 15 publications

(9 citation statements)

References 137 publications

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“…TCS has been used to reduce inflammation in the lesional skin of patients with AD [9][10][11]. However, while the long-term effects of these drugs on nonlesional skin, such as skin atrophy and barrier permeability dysfunction, have been reported, their effects on the TJ barrier are not well understood [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model

Koda

Ishii

Kashiwagi

et al. 2023

Skin Pharmacol Physiol

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Introduction: The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier deterioration. Moisturizers, such as mucopolysaccharide polysulfate (MPS), have been reported to prevent relapses in atopic dermatitis (AD) when used in combination with TCS. However, the mechanisms underlying the positive effects of MPS in combination with TCS in AD are poorly understood. In the present study, we investigated the effects of MPS in combination with clobetasol 17-propionate (CP) on tight junction (TJ) barrier function in human epidermal keratinocytes (HEKa) and 3D skin models. Methods: The expression of claudin-1, which is crucial for TJ barrier function in keratinocytes, and transepithelial electrical resistance (TEER) was measured in CP-treated human keratinocytes incubated with and without MPS. A TJ permeability assay, using Sulfo-NHS-Biotin as a tracer, was also conducted in a 3D skin model. Results: CP reduced claudin-1 expression and TEER in human keratinocytes, whereas MPS inhibited these CP-induced effects. Moreover, MPS inhibited the increase in CP-induced TJ permeability in a 3D skin model. Conclusion: The present study demonstrated that MPS improved TJ barrier impairment induced by CP. The improvement of TJ barrier function may partially be responsible for the delayed relapse of AD induced by the combination of MPS and TCS.

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Section: Discussionmentioning

confidence: 99%

“…Topical corticosteroids (TCS), which represent the current standard therapy for AD, have been used to reduce inflammation in lesional skin [9][10][11]. However, the long-term use of TCS is associated with several cutaneous side effects, such as skin atrophy and barrier impairment in both humans and animals [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model

Koda

Ishii

Kashiwagi

et al. 2023

Skin Pharmacol Physiol

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“…Topical corticosteroids (TCS) are one of the most used medications in dermatology (Das and Panda, 2017). TCS is the mainstay of therapy in many skin problems, ranging from inflammatory diseases to autoimmune disorders, due to its anti-inflammatory effects ( to successful treatment and avoidance of side effects include having an accurate diagnosis, selecting the correct drug, choosing an appropriate potency, delivery vehicle, frequency of application and duration of treatment as well as proper patient profiling (Rathi and D'Souza, 2012).…”

Section: Introductionmentioning

confidence: 99%

Topical corticosteroid phobia among high educational students in Al-Madinah region: A cross-sectional study

Mohanna¹,

Albeladi²,

Alshareef³

et al. 2023

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Background: Topical corticosteroid (TCS) phobia refers to patients' negative beliefs and ideas related to TCS use. This phenomenon is mostly caused by misinformation rather than an irrational fear, suggesting that the term TCS phobia is a misnomer. Objectives: To assess the prevalence of topical corticosteroid phobia among high educational students in Al-Madinah, Saudi Arabia. Methodology: A cross-sectional study was conducted in the 2022-2023 academic year using a pre-designed online questionnaire distributed through social media applications among university students in Al-Madinah, Saudi Arabia. The survey was composed of 13 questions. The data were analyzed by Statistical Package for Social Sciences (SPSS). Results: Among 485 participants, 46% of them were aged between 21-23 years old and 68% were female.Almost a quarter (22.5%) of them has used a topical corticosteroid; 22.9% of them were self-prescribed. Half of the users did not experience side effects and the most reported side effect was local skin irritation. Among non-users, fear of complications and concerns regarding its effectiveness were the most reported reasons that would prevent them from using TCS. Overall, TCS phobia and concerns were reported by 42.7% of the participants. The internet was the most common source of information. Conclusion: TCS are commonly used among young population in Al-Madinah. A considerable proportion was self-prescribed. TCS phobia is observed with misconceptions regarding the safety and efficacy of TCS. Health education is needed for this population to correct these misconceptions with involvement of healthcare professionals.

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“…Currently, the Medical Board of the National Psoriasis Foundation recommends low- to mild-potency topical corticosteroids as the first-line therapy [ 2 , 3 ]. Unfortunately, the well-known side effects associated with the prolonged use of steroids make these medicaments applicable only for short-term treatment, i.e., <4 weeks [ 13 , 14 ]. As the alternative first-line therapy for long-term treatment, although with a lower efficacy, topical calcineurin inhibitors (TCI), such as tacrolimus or pimecrolimus, and vitamin D analogues, are recognized by several studies [ 2 , 12 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Microbiota Modulation Induced by LimpiAL 2.5%, a New Medical Device for the Inverse Psoriasis Treatment

Pietrangelo

Dattola

Magnifico

et al. 2023

IJMS

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(1) Inverse psoriasis (IP), also known as intertriginous, typically affects the groin, armpits, navel, intergluteal fissure, and external genitalia. Skin lesions are erythematous plaques of inflammatory nature, smooth, well-delimited, non-scaly, and non-infiltrated. Lesions may be accompanied by itching, pain, or burning sensation. The aim of this study is both to investigate the modulation of the skin microbiota induced by IP and, on the other hand, to test the effectiveness of the new biotechnological product LimpiAL 2.5%. (2) Patients affected by IP were recruited in a private practice and treated for 4 weeks with LimpiAL 2.5% exclusively. The clinical effects on the lesion skin were evaluated, and the skin microbiotas before and after treatment were compared. (3) The clinical outcomes reveled a significant beneficial effect of the tested product. At the same time, LimpiAL increased the biological diversity of the skin microbiota and exerted a significant decrease of some Corynebacterium species, and the increase of some Staphylococcus species. (4) Together, the clinical outcomes and the microbiota analysis suggest that LimpiAL treatment improves the skin condition of affected patients, basically restoring the eubiosis conditions of the affected sites and modulating the bacterial composition of the resident microbiota.

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An Evidence Based Approach of Use of Topical Corticosteroids in Dermatology

Cited by 15 publications

References 137 publications

The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model

The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model

Topical corticosteroid phobia among high educational students in Al-Madinah region: A cross-sectional study

Efficacy and Microbiota Modulation Induced by LimpiAL 2.5%, a New Medical Device for the Inverse Psoriasis Treatment

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