Crosstalk, caused by unwanted interactions from the surrounding environment, remains a fundamental challenge in existing superconducting quantum computers (SQCs). We propose a method for qubit placement, connectivity, and logical qubit allocation on tunable-coupler SQCs to eliminate unnecessary qubit connections and optimize resources while reducing crosstalk errors. Existing mitigation methods carry trade-offs, like increasing qubit connectivity or software-based gate scheduling. Our method, the Context-Aware COupler REconfiguration (CA-CORE) compilation method, aligns with application-specific design principles. It optimizes the qubit connections for improved SQC performance, leveraging tunable couplers. Through contextual analysis of qubit correlations, we configure an efficient coupling map considering SQC constraints. We then apply the SWAP-based Bidirectional Heuristic Search (SABRE) qubit mapping method and crosstalk-adaptive scheduling to further optimize the quantum circuit. Our architecture reduces depth by an average of 18% and 27%, and by up to 50% and 60%, compared to lattice and heavy-hex architectures, respectively. With crosstalk optimization through adaptive scheduling, we achieve performance improvements of 35%, 20%, and 160% on fully-enabled grid, lattice, and heavy-hex topologies, respectively.