An examination of d-amphetamine self-administration in pedunculopontine tegmental nucleus-lesioned rats

Reduced Cocaine Self-Administration in Muscarinic M5Acetylcholine Receptor-Deficient Mice

“…Similar observations were reported in another investigation involving cholinergic/psychomotor stimulant interactions. Alderson et al (2004) lesioned the PPT in rats and observed decreased D-amphetamine selfadministration in an acquisition procedure and under a PR schedule but not under an FR schedule in animals pretrained with food. One possible explanation is that the contribution of cholinergic systems to the reinforcing effects of psychomotor stimulants is most clearly observed at threshold levels of reinforcement.…”

Attenuation of d-amphetamine self-administration by baclofen in the rat: behavioral and neurochemical correlates

“…In animals that received saline or 3.2 mg/kg baclofen, the priming injection resulted in an increase in extracellular DA concentrations; however, only saline-treated animals initiated self-administration, and showed elevated DA levels throughout the course of the session. Baclofen-treated animals failed to initiate self-administration after the priming injection and NAc DA efflux was blunted when self-administration did occur later in the test session nucleus (PPTg), a structure that receives glutamatergic and GABAergic input and which is implicated in rewardrelated behavior, decreases PPTg DA release, while Alderson et al (2004) report that lesions of the PPTg attenuate dAMPH IVSA, possibly as a result of alterations in striatal DA activity.…”

Roles of pedunculopontine tegmental cholinergic receptors in brain stimulation reward in the rat

“…PPTg is suggested as a limbic-motor interface involved in the mediation of mesencephalic locomotor activities, sleep-wakefulness cycle, sensorimotor gating, and reward-related behaviors as well (Pahapill and Lozano 2000;Mena-Segovia et al 2004;Diederich and Koch 2005). Of these, the involvement of PPTg in reward-related behaviors has been demonstrated in conditioned place preference (Tzschentke 1998;Kippin and van der Kooy 2003), intravenous drug self-administration (Olmstead et al 1998;Lanca et al 1999;Corrigall et al 1999Corrigall et al , 2001Corrigall et al , 2002Picciotto and Corrigall 2002;Alderson et al 2004), and intracranial electrical self-stimulation (Yeomans et al 1993;Nakahara et al 2001).…”