An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD1

Welch, C. M.; Thornton, Kara J; Murdoch, Gordon K.; Chapalamadugu, Kalyan C.; Schneider, Cibele Regina; Ahola, Jason K.; Hall, J. B.; Price, William J.; Hill, Rodney A.

doi:10.2527/jas.2013-6609

Cited by 11 publications

(4 citation statements)

References 47 publications

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“…reported that the genetic relationship between plasma IGF-I concentration and RFI becomes less positive as cattle mature physiologically. Thus, the genes associated with systemic IGF-I concentration differ between the post-weaning and finishing stages of development 43 . As a consequence, the concentration of serum IGF-1 may not be an appropriate indicator of RFI in sheep.…”

Section: Discussionmentioning

confidence: 99%

Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs

Zhang

Wang

et al. 2017

Sci Rep

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The aim of this study was to determine the association of residual feed intake (RFI) with growth performance, blood metabolic parameters, and body composition factors in growing lambs. Individual body weight (BW) and dry matter intake (DMI) were determined in 137 male Hu lambs that were given a pellet feed four times a day for 50 d. RFI did not show a correlation with metabolic BW (MBW) or average daily gain (ADG), but it showed a positive correlation with DMI and feed conversation ratio (FCR). Organ weight and intestine length had a large influence on RFI in lambs. The low-RFI lambs have smaller rumen and longer duodenum indicating the less feed intake and more sufficient absorption rate of low-RFI lambs. The smaller organs like liver, lung and kidney in low-RFI lambs may be related to lower energy consumption and slower metabolic rate. The observed bigger testis was in low-RFI lambs was another cause of the improved feed efficiency. Finally, the plasma concentrations of thyroxine (T4) and adrenocorticotropic hormone (ACTH) were lower in the ELow-RFI group than in the EHigh-RFI group. This study provides new insight into the biological processes underlying variations in feed efficiency in growing lambs.

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Section: Discussionmentioning

confidence: 99%

Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs

Zhang

Wang

et al. 2017

Sci Rep

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“…In terms of circulating concentrations of IGF-I, some studies have reported higher (Nascimento et al, 2015), others lower (Lancaster et al, 2008) or no difference (Lawrence et al, 2012;Welch et al, 2013) in concentrations between lowand high-RFI cattle. Plasma concentrations of insulin at the end of a test period were found to be higher in the steer progeny of high-compared with low-RFI parents (Richardson et al, 2004).…”

Section: Nutrient Partitioning: Protein and Fat Depositionmentioning

confidence: 99%

Invited review: Improving feed efficiency of beef cattle – the current state of the art and future challenges

Kenny

Fitzsimons

Waters

et al. 2018

Animal

170

135

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Improvements in feed efficiency of beef cattle have the potential to increase producer profitability and simultaneously lower the environmental footprint of beef production. Although there are many different approaches to measuring feed efficiency, residual feed intake (RFI) has increasingly become the measure of choice. Defined as the difference between an animal's actual and predicted feed intake (based on weight and growth), RFI is conceptually independent of growth and body size. In addition, other measurable traits related to energy expenditure such as estimates of body composition can be included in the calculation of RFI to also force independence from these traits. Feed efficiency is a multifactorial and complex trait in beef cattle and inter-animal variation stems from the interaction of many biological processes influenced, in turn, by physiological status and management regimen. Thus, the purpose of this review was to summarise and interpret current published knowledge and provide insight into research areas worthy of further investigation. Indeed, where sufficient suitable reports exist, meta-analyses were conducted in order to mitigate ambiguity between studies in particular. We have identified a paucity of information on the contribution of key biological processes, including appetite regulation, post-ruminal nutrient absorption, and cellular energetics and metabolism to the efficiency of feed utilisation in cattle. In addition, insufficient information exists on the relationship between RFI status and productivity-related traits at pasture, a concept critical to the overall lifecycle of beef production systems. Overall, published data on the effect of RFI status on both terminal and maternal traits, coupled with the moderate repeatability and heritability of the trait, suggest that breeding for improved RFI, as part of a multi-trait selection index, is both possible and cumulative, with benefits evident throughout the production cycle. Although the advent of genomic selection, with associated improved prediction accuracy, will expedite the introgression of elite genetics for feed efficiency within beef cattle populations, there are challenges associated with this approach which may, in the long-term, be overcome by increased international collaborative effort but, in the short term, will not obviate the on-going requirement for accurate measurement of the primary phenotype.

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“…However, the systemic IGF-I concentration is known to be influenced by environment also [7] [14]. In the contrary, a positive genetic relationship between plasma IGF-I level and RFI in sheep [35] has been reported. RFI DEGs may not be comparable with respect to age, breed and physiological status.…”

Section: System Biology Analysismentioning

confidence: 99%

Functional Genes in Relation to Residual Feed Intake in Murrah Buffalo Heifers

Sikka¹,

Paul²,

Adnot³

et al. 2023

ABB

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High Feed efficiency (FE) in growing heifers has economic importance in dairy, but remains less understood in buffaloes. Feed conversion efficiency is defined as dry matter intake (DMI) per unit body weight gain and is determined as residual feed intake (RFI), i.e., the difference between actual and predicted feed intake to gain unit body weight during a feed trial run for 78 days under control feeding. A large variation was identified ranging between −0.42 to 0.35 in growing buffalo heifers (n = 40) of age between 11 to 15 months. An average daily weight gain (ADG) varied between 382.0 and 807.6 g/day when compared with the control-fed heifers at an organized buffalo farm. The whole blood transcriptome data obtained from the selected growing heifers from extremes of estimated high and low RFI efficiency were compared with the reference assembly generated from the transcriptome of multiparous buffaloes (n = 16) of diverse age of maturity, period of regaining post partum cyclicity and level of milk production. Differentially expressed genes (DEGs) were identified using the reference genome of Mediterranean water buffalo. GO: terms (Padj < 0.05, FDR < 0.05) enriched by annotated DEGs and biological pathways in gene network for RFI efficiency trait were identified. GO: terms specific to pre-transcriptional regulation of nucleus and Chromatin organization under Nucleoplasm, Energy balancing, Immunity, Cell signaling, ROS optimization, ATP generation through the Electron Transport chain and cell proliferation were determined. The study reveals the indicators targeting the actual metabolic changes and molecular functions underlying the feed utilization capacity of buffaloes. Estimated RFI efficiency revealed a large variation over heifers which may lower the DMI even up to 13.6% thus, enabling an increase in ADG up to 16% by involving efficient heifers in breeding plan. The study revealed a scope of high gain by selective

show abstract

An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD1

Cited by 11 publications

References 47 publications

Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs

Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs

Invited review: Improving feed efficiency of beef cattle – the current state of the art and future challenges

Functional Genes in Relation to Residual Feed Intake in Murrah Buffalo Heifers

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