“…Various Gly-derived upgraded structures with enhanced properties and extended application profiles are well-described. Solketal [ 6 ] and other acetals, 1,3-propanediol [ 7 , 8 ] and dihydroxy acetone [ 9 ], represent known examples, and among these, a leading position is occupied by glycerol carbonate (GC), which represents the main focus of this work. As a multiple-site electrophile, GC can efficiently and selectively interact with diverse nucleophiles, such as amines [ 10 , 11 , 12 ], amino acids [ 13 , 14 ], phenols [ 15 ], carboxylates [ 16 ], and others [ 17 ].…”