An Expedient Phase Transfer Catalyst‐Mediated Synthesis of 2‐Alkyl/Aryl‐1,8‐phenanthrolines

Abstract

Several 2-alkyl and 2-aryl-1,8-phenanthrolines were synthesized efficiently from 5-aminoisoquinoline and seven α,β-unsaturated aldehydes in aq. HCl-toluene mixture at 100°C using benzyltriethylammonium chloride as a phase transfer catalyst.

An expedient general synthesis of pyrrolo[3,2-e]indazoles: domino Sonogashira/Cacchi coupling-heteroannulation reactions

“…3 Substituted indazoles too are of considerable pharmaceutical importance because of their therapeutic potential and use, 4 amongst which benzydamine is a notable anti-inflammatory agent. 5,6 In continuation of our ongoing interest in the development of general synthetic routes to potentially bioactive condensed nitrogen heterocycles, [7][8][9][10][11][12][13][14] we recently focused our attention on a relatively less studied class of heterocycles which incorporate both the indole and the indazole nuclei, viz. pyrazoloindoles which may also be regarded as pyrroloindazoles.…”