An expedient synthesis of new imino-thiazolidinone grafted dispiro-pyrrolidine-oxindole/indeno hybrids via a multicomponent [3+2] cycloaddition reaction in a deep eutectic solvent

Abstract

A facile and selective synthesis of novel factionalized dispiro-pyrrolidines via a three component [3+2] cycloaddition reaction using a deep eutectic solvent.

A Bird's‐Eye View on Deep Eutectic Solvent‐Mediated Multicomponent Synthesis of N‐Heterocycles

“…A series of molecules were synthesized due to propitious functional group toleration, these molecules are now being biologically screened and the results were promising (Scheme 7). [41] …”

Choline Chloride-Based DES as Solvents/Catalysts/Chemical Donors in Pharmaceutical Synthesis

“…From a synthetic chemistry point of view, the above illustrated 2-imino-4-thiazolidinones are very interesting scaffolds, due to the presence of electrophilic centers and activated exocyclic double bonds, and therefore they can behave like dipolarophiles in 1,3-dipolar cycloaddition reactions. In this context, Singh et al have used 2-iminothiazolidin-4-ones as a core system for the construction of hybrids with spiro-oxindole-pyrrolidines as novel druglike molecules [ 73 ]. The preparation of hybrids was carried out with excellent yields (50–92%) and high regio- and stereo-selectivity by means of the multicomponent 1,3-dipolar cycloaddition of (2Z)-methyl-2-[(Z)-4-oxo-3-aryl-2-(arylimino) thiazolidin-5-ylidene] acetate as dipolarophile with substituted isatins and sarcosine, using ChCl/urea as the green solvent ( Scheme 12 ).…”

Functionalized thiazolidone-decorated lanthanum-doped copper oxide: novel heterocyclic sea sponge morphology for the efficient detection of dopamine

“…In this respect, thiazolidone and its derivatives are the privileged core of N-, S-and O-containing bioactive heterocycles and have been extensively exploited as a scaffold for biological activities, drug development and uorescent sensors. [26][27][28] They tend to interact with transition metals with different structural patterns owing to the presence of S, O and N and have the possibility to develop supra-molecular infrastructures with ideal stability that made them the ultimate choice for sensing usage. 29,30 However, still there is great room to further improve their intrinsic features such as charge carrier density and electrical conductivity by enhancing S and N contents.…”