An expeditious on-water regioselective synthesis of novel arylidene-hydrazinyl-thiazoles as DNA targeting agents

Design, synthesis and characterization of tetra substituted 2,3-dihydrothiazole derivatives as DNA and BSA targeting agents: advantages of the visible-light-induced multicomponent approach

“…Furthermore, the diazo N atoms at N-9 ( δ 346.5 ppm) and N-10 ( δ 278.1 ppm) shows correlation peaks with methylene protons ( δ 8.36 ppm) at C-7 position. 28 Lastly, the N atom ( δ 278.2 ppm) displays cross peaks with methine protons ( δ 10.13 ppm) at C-6 position. These outcomes are in great agreement with our previous results related to the regioselective synthesis of thiazole derivative where carbonyl carbon was found next to the aryl ring and methyl group at C-4 position of the thiazole ring.…”

“…Our research group has been enthusiastically indulged in the synthesis of aza-heterocycles using green protocols such as solvent free grinding, 26,27 use of green solvents 28,29 and multi-component approach. 30,31 Also, our research group has investigated the use of visible light as a sustainable energy source for the synthesis of aza-heterocycles, primarily azoles and exploring the possible biological applications of synthesized compounds as DNA binding agents.…”

Serendipitous N,S-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders

“…The quenching constant (K q = 5.86 ± 0.11 × 10 12 M −1 s −1 ) was found to be higher than the scattering constant (10 10 L mol −1 s −1 ), indicating that the quencher 14m forms a complex with DNA through static quenching. 33 The value of the slope of the graphs determines the Stern-Volmer constant (K sv ) (eqn (1)).…”

Synthesis of Imidazole‐2,3‐dihydrothiazole Compounds as VEGFR‐2 Inhibitors and Their Support with in Silico Studies

“…The thiazole ring is very useful in terms of biological activity. There is a lot of literature information showing its anticancer and antifungal activity [10–17] . In addition to this information, there is also a study using the thiazole ring as a VEGFR‐2 inhibitor [18] .…”

“…There is a lot of literature information showing its anticancer and antifungal activity. [10][11][12][13][14][15][16][17] In addition to this information, there is also a study using the thiazole ring as a VEGFR-2 inhibitor. [18] When docking studies are examined, the interaction of the thiazole ring with Asp1046, which is an important amino acid for the enzyme, shows the potential of the ring to inhibit VEGFR-2.…”