An Expeditious Route for the Synthesis of Thiadiazolo - Pyrimidin - 2- Thiones Using Microwaves

Abstract

A series of 1-(1,3,4-thiadiazolo)-2-thioxo-pyrimidines 4a-g are synthesized by the condensation of monosubsituted thioureas la-g, ethyl acetoacetate 2 and arylaldehyde 3 in dry media using microwave irradiation. The reactions are completed in very short time with high yield. The use of inorganic solid supports has been proved as an alternative mean of synthetic media.

Alumina Supported Synthesis of Some α,β– Unsaturated Heterocyclic Acids

“…This method requires shorter reaction time and easy work-up with better yield. 24 one-pot method involves the condensation of reactants in one step to produce the target molecules. On the top of this, synthesis in aqueous media has gained popularity as it is an eco-friendly and economic method which avoids the use of hazardous solvents, acids and bases in the synthetic steps.…”