“…Of this number, 11 patients were definitely not in the first attack of their disease; this finding is similar to that of Jalan, Sircus, Card, Falconer, Bruce, Crean, McManus, Small, and Smith (1969a) who found that, of 16 patients who sustained perforation, 11 did so during a relapse and only five in their first attack. Other authors (Edwards and Truelove, 1964;de Dombal, Watts, Watkinson, and Goligher, 1965) have found perforation to be more common during the initial attack of ulcerative colitis.…”