An Experimental Comparison of the Effects of Propolis, Curcumin, and Methylprednisolone on Crush Injuries of the Sciatic Nerve

Yüce, Serdar; Gökçe, Emre Cemal; Işkdemir, Ahmet; Koç, Emine Rabia; Cemil, Duran Berker; Gökçe, Aysun; Sargon, Mustafa F.

doi:10.1097/sap.0000000000000026

Cited by 32 publications

(48 citation statements)

References 32 publications

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“…Regeneration and repair process follow nerve injury can be impaired due to the oxidative stress 1,2 . Antioxidants may alleviate the adverse effects of free oxygen radicals on nerve regeneration 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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PURPOSE:To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS:Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve: Group I: ozone (20mcg/ml); Group II: methylprednisolone (2mg/kg); Group III: ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV: isotonic saline (0.9%). The histomorphological evaluation was made after biopsies were obtained from the sites of injury.RESULTS: Significant differences were noted between groups in terms of degeneration (p=0.019), nerve sheath cell atrophy (p=0.012), intraneural inflammatory cellular infiltration (p=0.002), perineural granulation tissue formation (p=0.019), perineural vascular proliferation (p=0.004), perineural inflammatory cellular infiltration (p<0.001) and inflammation in peripheral tissue (p=0.006).Degeneration was remarkably low in Group III, while no change in nerve sheath cell was noted in Group II. CONCLUSION:The combined use of methylprednisolone and ozone treatment can have beneficial effects for regeneration after crush type nerve injury.

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Section: Introductionmentioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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“…The etiological identification of the affected lesions is highly diverse (it can include elongation, section, laceration, crushing) (Caillaud et al, 2018[4]). Consequently, any erroneous or improper treatment can lead to loss of sensory, motor and autonomous functions (Yüce et al, 2015[45]). Approximately, 24-48 hours after the neuronal damage, the Wallerian degeneration sets in, a series of cellular and molecular changes.…”

Section: Introductionmentioning

confidence: 99%

Comparison of melatonin and curcumin effect at the light and dark periods on regeneration of sciatic nerve crush injury in rats

Kasmaie

Jahromi

Gazor

et al. 2019

EXCLI Journal; 18:Doc653; ISSN 1611-2156

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“…It improves the neuroregeneration process after sciatic nerve injury [20][21][22] . Moreover, it has a protective role on cisplatin-induced neurotoxicity in rats [23] .…”

Section: Chemotherapy Induced Peripheral Neuropathy (Cipn)mentioning

confidence: 99%

“…More than 150 compounds are found in propolis but it is composed mainly of polyphenols and flavonoids [16] . It has a wide range of biological and pharmacological activities including anticancer, anti-inflammatory, antioxidant, antimicrobial [17,18] , anti-apoptotic, antiviral, antifungal, hepatoprotective, cardioprotective, immunomodulatory, anti-diabetic, local anesthetic effect and neuroprotective effects [19][20][21] .…”

Section: Chemotherapy Induced Peripheral Neuropathy (Cipn)mentioning

confidence: 99%

The Possible Role of Propolis in Ameliorating Paclitaxel-Induced Peripheral Neuropathy in Sciatic Nerve of Adult Male Albino Rats

Kassab

Elkaliny

2017

Egyptian Journal of Histology

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Background: Paclitaxel is a neurotoxic chemotherapeutic agent. The sensorimotor peripheral neuropathy is a serious dose limiting complication of paclitaxel therapy. Propolis is a natural honeybee product collected from plants. It has broad biological and pharmacological activities and a proposed neuroprotective role. Aim: To assess the possible protective role of propolis on paclitaxel-induced peripheral neuropathy in rat's sciatic nerve. Material and Methods: Twenty-four adult male albino rats were divided into four equal groups; control group, propolistreated group (50 mg/kg orally once daily), paclitaxel -treated group (16 mg/kg intraperitoneally once a week), and both paclitaxel & propolis-treated group. Animals were treated for 5 consecutive weeks. Specimens of sciatic nerve were processed for histological study by light and electron microscopy. Immunohistochemical study was carried out using CD68 antibody. Morphometric study and statistical analysis of light microscopic data were performed for all groups. Results: Compared to the control group, the sciatic nerve specimens of the paclitaxel-treated rats showed splitting of myelin lamellae with infolded myelin loops, together with invagination and evagination of the myelin sheath. Changes in the axons included formation of myelin figures, compression and irregularity. Schwann cells showed cytoplasmic vacuolation and dilated rER. Immunohistochemical study revealed a significant increase in the number of CD68 positive cells. On the other hand, minimal changes were observed in rats treated concomitantly with both paclitaxel and propolis, with a non-significant increase in CD68 positive cells. Conclusion: Paclitaxel induced structural changes in the myelinated fibers of sciatic nerve of albino rats. The concomitant treatment with propolis ameliorated these changes.

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An Experimental Comparison of the Effects of Propolis, Curcumin, and Methylprednisolone on Crush Injuries of the Sciatic Nerve

Abstract: Curcumin and propolis, 2 traditional drugs, had a positive effect on nerve crush injuries. We are convinced that they can be used to support routine treatment in such nerve injuries.

Cited by 32 publications

References 32 publications

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

Comparison of melatonin and curcumin effect at the light and dark periods on regeneration of sciatic nerve crush injury in rats

The Possible Role of Propolis in Ameliorating Paclitaxel-Induced Peripheral Neuropathy in Sciatic Nerve of Adult Male Albino Rats

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