An experimental evaluation of compressibility effects in syringe pumps for liquid chromatography

Achener, P.Y.; Abbott, Seth R.; Stevenson, Robert Louis

doi:10.1016/s0021-9673(00)89778-2

Cited by 14 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26870, Waters Assoc., Milford, Massachusetts 01757) and sonicated to minimize outgassing resulting from the syringe pump system. 34 Optimum conditions for separating components of a mixture could be established using the JASCO micro liquid chromatograph in the conventional off -line mode. For best micro LCMS re;ults, flow rates should be maintained at 8 pl min-, and eluants containing inorganic acids and buffers should be avoided.…”

Section: Methodsmentioning

confidence: 99%

Drug analysis by direct liquid introduction micro liquid chromatography mass spectrometry

Henion

Maylin

1980

Biol. Mass Spectrom.

View full text Add to dashboard Cite

The analytical capabilities of a micro high performance liquid chromatograph interfaced to an unchanged quadrupole mass spectrometer are presented. Continuous monitoring of the total micro liquid chromatographic effluent allows full scan chemical ionization mass spectra of from one to five nanograms of drugs and their metabolites to be recorded. The interface is a simple, inexpensive device which can be assembled from commercially available components. An eight microliter per minute flow rate of the micro liquid chromatographic eluant allows separation and identification of biologically important substances not amenable to gas chromatography mass spectrometry techniques. The sensitivity of micro liquid chromatography mass spectrometry performed as described is comparable with gas chromatography mass spectrometry and is achieved by introducing the total micro liquid chromatographic effluent into the chemical ionization ion source of the mass spectrometer. Selected ion monitoring provides 20 pg detection limits of phenothiazine tranquilizers injected on column.

show abstract

Section: Methodsmentioning

confidence: 99%

Drug analysis by direct liquid introduction micro liquid chromatography mass spectrometry

Henion

Maylin

1980

Biol. Mass Spectrom.

View full text Add to dashboard Cite

show abstract

Evaluation of a microHPLC system dedictaed to packed capillary column liquid chromatography

Trisciani¹,

Andreolini²

1990

J. High Resol. Chromatogr.

View full text Add to dashboard Cite

Miniaturization and optimization of the solvent delivery system, mixing device, and detection system for gradient elution at few μl/min is the most important objective of instrumental development in microHPLC using packed capillary columns. Instrumental solutions and evaluation of the performence of a dedicated system for automatic gradient elution with packed capillary columns are reported. Retention time precision shown buy the system results in an RSD of 0.20–0.52% for a PAH model mixture eluted under gradient conditions at few μl/min. Compositional accuracy of gradient profiles is also demonstrated.

show abstract

Literatur

Eppert¹

1979

Einführung in Die Schnelle Flüssigchromatographie

View full text Add to dashboard Cite

An experimental evaluation of compressibility effects in syringe pumps for liquid chromatography

Cited by 14 publications

References 3 publications

Drug analysis by direct liquid introduction micro liquid chromatography mass spectrometry

Drug analysis by direct liquid introduction micro liquid chromatography mass spectrometry

Evaluation of a microHPLC system dedictaed to packed capillary column liquid chromatography

Literatur

Contact Info

Product

Resources

About