An Experimental Evaluation of Possible Teratogenic Potential in<i>Boerhaavia diffusa</i>in Albino Rats

Singh, Anubha; Singh, R; Singh, R. H.; Mishra, Neha; Singh, Nidhi

doi:10.1055/s-2006-960105

Cited by 10 publications

(6 citation statements)

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“…It was tested for the presence of alkaloids. In a previous study the extract does not showed any sign of toxicity up to an oral dose of 2g/Kg in mice (Chandan et al, 1991), and an oral administration of 250mg/Kg to pregnant Albino rats during the entire gestation period was found to be devoid of any teratogenic effect (Sing et al, 1991). Hence the concentration used in this study (25mg/Kg, route i.p.)…”

Section: Extract Preparationmentioning

confidence: 75%

Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice

2005

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Section: Extract Preparationmentioning

confidence: 75%

Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice

2005

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“…An assessment of the ethanol extract showed no increase in cellular volume and protein content in H9C2 cells . The safety of extracts has also been observed in vivo …”

Section: Discussionmentioning

confidence: 91%

“…[17] The safety of extracts has also been observed in vivo. [38,39] Reactive oxygen species have been identified as one of the key players in the maintenance of cellular physiology by regulating diverse downstream signalling pathways leading to specific functions such as cellular division, growth, apoptosis and necrosis. [8,40,41] However, excessive generation of ROS may result in cellular deterioration.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of oxidative stress and artificial wound closure in C2C12 myoblasts induced by sequential extracts of Boerhavia diffusa

Yahaya

Cordier

Steenkamp

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment of wounds and other ailments. The aim of the study was to determine the ability of sequential extracts of B. diffusa to influence oxidation and wound closure in myoblast cells in vitro.Methods Sequential extracts were prepared from the whole plant using four solvents of increasing polarity (hexane, ethyl acetate, methanol and water). Cytotoxicity was determined using the sulforhodamine B staining assay, phase-contrast microscopy, plasDIC microscopy and live-dead staining. Extracts were tested for their ability to reduce 2,2 0 -azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidation and mediate cell migration after artificial wound generation in C2C12 myoblast cells using the scratch wound assay. Key findings All extracts indicated negligible cytotoxicity (IC 50 > 100 lg/ml), and microscopic evaluation showed no difference from negative controls. AAPH induced a 2.87-fold increase in reactive oxygen species compared to the negative control. Pretreatment with 100 lg/ml of the extracts reduced AAPH-induced oxidation to 1.70-fold of the untreated controls (P < 0.001). Wound closures in the methanol and water extract treatments were 18.08% and 20.76% higher than the negative control, respectively (P < 0.01). Conclusions These findings indicate that the hexane, methanol and water extracts of B. diffusa whole plant promote artificial wound healing and protection against oxidation in vitro and therefore warrant further research into its mechanisms of wound healing.

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“…It is antibacterial, antioxidant and antidiabetic. It contains arachidic acid, behenic acid, saturated fatty acids, vitamins C, lignin, phenolics, steroids, glycosides and boeravinone B …”

Section: Management Of Utimentioning

confidence: 99%

Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review

Shaheen

Akram

Jabeen

et al. 2019

Clin Exp Pharma Physio

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Urinary tract infection (UTI) is one of the most severe public health problem affecting both sexes but females are more susceptible due to the differences in urogenital and reproductive anatomy, physiology and lifestyle. As in UTI, different parts of the urinary tract are affected and morbidity due to UTI is more common in women of all ages and older men. Due to multi-drug resistant strains and high recurrence rate, UTI has become a major socioeconomic burden. The current review article was aimed to describe the natural therapeutic strategies to manage and cure the UTI. For this purpose, different databases including Google Scholar, Cochrane database, and PubMed etc. were explored. Inclusion criteria were any research article investigating the current therapy of UTI. It was found that microbial infections including Escherichia coli, Enterococcus faecalis and Klebsiella species are the major causes of UTI with different signs and symptoms including painful urination or dysuria, hematuria, urinary urgency, burning micturition, frequent urination, nausea, and vomiting. Antibiotics like trimethoprim, sulfamethoxazole, quinolone etc. as the first choice of the drug are used worldwide. However, due to microbial resistance, several life-threatening side effects, repeated high doses, high cost and low efficacy of these antibiotics motivated the researchers to explore natural remedies for the treatment of UTI. Herbal medicines are effective to combat bacterial resistance with high efficacy, and easy availability with minimal or no side effects. For these reasons it has attained the attention of researchers wanting to explore the herbal treatment of UTI. Vaccinium macrocarpon, Tribulus terrestris, Trachyspermum copticum, Cinnamomum verum and Hybanthusenn easpermus are some common medicinal plants reported to have therapeutic potential for the management and cure of the UTI. Although herbal medicines have more potential over conventional medicine but more discoveries are required to explore the phytoconstituents and their mechanism of action responsible for the management and cure of UTI.

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An Experimental Evaluation of Possible Teratogenic Potential inBoerhaavia diffusain Albino Rats

Cited by 10 publications

References 0 publications

Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice

Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice

Attenuation of oxidative stress and artificial wound closure in C2C12 myoblasts induced by sequential extracts of Boerhavia diffusa

Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review

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